Derek Lowe (chemist) explained
Derek Lowe is a medicinal chemist working on preclinical drug discovery in the pharmaceutical industry. Lowe has published a blog about this field, "In the Pipeline", since 2002[1] and is a columnist for the Royal Society of Chemistry's Chemistry World.[2]
Biography
Lowe (born in Harrisburg, Arkansas) got his BA from Hendrix College and his PhD in organic chemistry from Duke University on synthesis of natural products, before spending time in Germany on a Humboldt Fellowship.[3]
Lowe was one of the first people to blog from inside the pharmaceutical industry, with the approval of his supervisor and the company legal department,[4] and one of the first science bloggers.[5] By 2006, his blog had between 3,000 and 4,000 visitors per day during the workweek; he covered business matters, trends and issues in medicinal chemistry, and legal matters like patent law and regulation.[6] At that time he was working at a pharmaceutical company doing hit to lead medical chemistry work.[6] his blog received between 15,000 and 20,000 page views on a typical weekday.[7] His response to a 2013 article in BuzzFeed that propagated chemophobia was widely cited.[8] [9] [10]
He serves on the editorial board of ACS Medicinal Chemistry Letters and on the advisory board of Chemical & Engineering News.[11]
he was working at Novartis; formerly he had worked for 10 years at Vertex, 9 years at Bayer, and 8 years at Schering-Plough.[12] [13] [14]
Notable publications
Book
- Book: Lowe. Derek B.. The Chemistry Book: From Gunpowder to Graphene, 250 Milestones in the History of Chemistry . 2016. Sterling. 9781454911807. en.
Selected scientific papers
- Greenlee. W. Clader. J. Asberom. T. McCombie. S. Ford. J. Guzik. H. Kozlowski. J. Li. S. Liu. C. Lowe. D. Vice. S. Zhao. H. Zhou. G. Billard. W. Binch. H. Crosby. R. Duffy. R. Lachowicz. J. Coffin. V. Watkins. R. Ruperto. V. Strader. C. Taylor. L. Cox. K. Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.. Farmaco . April 2001. 56. 4. 247–50. 11421251. 2. 10.1016/s0014-827x(01)01102-8.
- Lowe. DB. Magnuson. S. Qi. N. Campbell. AM. Cook. J. Hong. Z. Wang. M. Rodriguez. M. Achebe. F. Kluender. H. Wong. WC. Bullock. WH. Salhanick. AI. Witman-Jones. T. Bowling. ME. Keiper. C. Clairmont. KB. In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.. Bioorganic & Medicinal Chemistry Letters. 21 June 2004. 14. 12. 3155–9. 10.1016/j.bmcl.2004.04.015. 15149665. 2.
- Rudolph. J. Esler. WP. O'connor. S. Coish. PD. Wickens. PL. Brands. M. Bierer. DE. Bloomquist. BT. Bondar. G. Chen. L. Chuang. CY. Claus. TH. Fathi. Z. Fu. W. Khire. UR. Kristie. JA. Liu. XG. Lowe. DB. McClure. AC. Michels. M. Ortiz. AA. Ramsden. PD. Schoenleber. RW. Shelekhin. TE. Vakalopoulos. A. Tang. W. Wang. L. Yi. L. Gardell. SJ. Livingston. JN. Sweet. LJ. Bullock. WH. Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.. Journal of Medicinal Chemistry. 18 October 2007. 50. 21. 5202–16. 10.1021/jm070071+. 17887659. 2.
- Arrowsmith. CH. Audia. JE. Austin. C. Baell. J. Bennett. J. Blagg. J. Bountra. C. Brennan. PE. Brown. PJ. Bunnage. ME. Buser-Doepner. C. Campbell. RM. Carter. AJ. Cohen. P. Copeland. RA. Cravatt. B. Dahlin. JL. Dhanak. D. Edwards. AM. Frederiksen. M. Frye. SV. Gray. N. Grimshaw. CE. Hepworth. D. Howe. T. Huber. KV. Jin. J. Knapp. S. Kotz. JD. Kruger. RG. Lowe. D. Mader. MM. Marsden. B. Mueller-Fahrnow. A. Müller. S. O'Hagan. RC. Overington. JP. Owen. DR. Rosenberg. SH. Roth. B. Ross. R. Schapira. M. Schreiber. SL. Shoichet. B. Sundström. M. Superti-Furga. G. Taunton. J. Toledo-Sherman. L. Walpole. C. Walters. MA. Willson. TM. Workman. P. Young. RN. Zuercher. WJ. The promise and peril of chemical probes.. Nature Chemical Biology. August 2015. 11. 8. 536–41. 10.1038/nchembio.1867. 26196764. 4706458. 2.
Selected blogs or commentary
External links
- Lowe's "In the Pipeline" blog
- Columns at Chemistry World
- Lowe. D. An interview with Derek Lowe.. Trends in Pharmacological Sciences. March 2013. 34. 3. 147–8. 10.1016/j.tips.2013.01.003. 23462513.
- News: Interview: Derek Lowe. The Sceptical Chymist: A Nature Chemistry blog. 18 May 2007. 1 August 2010. 4 July 2008. https://web.archive.org/web/20080704192733/http://blogs.nature.com/thescepticalchymist/2007/05/reactions_derek_lowe_1.html. dead.
- Reddit AMA, 28 February 2014
Notes and References
- News: Weintraub. Karen. Derek Lowe: Chemist puts a human face on drug development. STAT. 5 March 2016.
- Web site: Derek Lowe . Chemistry World .
- Web site: Odyssey Medal: Derek Lowe. Hendrix College. en. 2014.
- Web site: https://web.archive.org/web/20110514113329/http://www.the-scientist.com/article/display/15665/. 2011-05-14 . The Power of the Blog . The Scientist . August 2005. David . Secko.
- Web site: The oldest science blog of all? | Gene Expression | Discover Magazine . Blogs.discovermagazine.com . 2010-08-24 . 2012-02-22 . 2012-10-16 . https://web.archive.org/web/20121016140950/http://blogs.discovermagazine.com/gnxp/2010/08/the-oldest-science-blog-of-all/ . dead .
- News: Raber. Linda R.. Moving Away From Target-Based Discovery. Chemical & Engineering News. June 19, 2006.
- News: Jarvis. Lisa. Pharma Blogging Panel at ACS Boston. The Haystack. 24 August 2010.
- News: Foods Ingredients Banned Outside the US. ABC News. 26 June 2013. en.
- News: Nosowitz. Dan. Chemist Says BuzzFeeᴅ Article About Food Chemistry Has "Serial Stupidities". Popular Science. June 21, 2013. en.
- News: Jogalekar. Ashutosh. Where's the chemistry lobby? On why we need a National Center for Chemical Education. Scientific American Blog Network. July 11, 2013. en.
- Baum. Rudy M.. C&EN In The Blogosphere. Chemical & Engineering News. 3 May 2010. 88. 18. 3. 10.1021/cen-v088n018.p003. free.
- Web site: Derek Lowe. LinkedIn. 29 May 2018.
- News: Lieu. Chris. BioCentury - Lowe parts ways with Vertex amid reorganization. Biocentury. 28 March 2017. en.
- Chemjobber. Layoffs and the midcareer chemist. Chemical & Engineering News. November 20, 2017. 95. 46.