| Post: | Deputy Prime Minister |
| Native Name: | نائب رئيس الوزراء السوري |
| Body: | the Syrian Arab Republic |
| Insignia: | Seal of the Prime Minister of Syria.svg |
| Insigniacaption: | Seal of the deputy prime minister of Syria |
| Insigniasize: | 120px |
| Style: | Mr Deputy Prime Minister His Excellency |
| Status: | Third highest in executive branch |
| Nominator: | Prime Minister |
| Residence: | Government building, Damascus, Syria |
| Appointer: | President |
| Reports To: | Prime Minister |
| Member Of: | Council of Ministers |
| Termlength: | No term limits |
| Inaugural: | Mustafa Nehmeh (kingdom) Lutfi al-Haffar (republic) |
The deputy prime minister of Syria (Arabic: نائب رئيس الوزراء السوري) is the deputy to the prime minister of Syria, who is head of the government of Syria, and a member of the Council of Ministers. The deputy prime minister is the second highest-ranking member of the Council of Ministers. In the semi-presidential system of government, the prime minister is treated as the "first among equals" in the cabinet; the position of deputy prime minister is used to bring political stability and strength within a government or in times of national emergency, when a proper chain of command is necessary. As of 2023, the post is Vacant.