| Depot Creek | |
| Pushpin Map: | Canada Southern Ontario |
| Pushpin Map Caption: | Location of the mouth of Depot Creek in southern Ontario |
| Subdivision Type1: | Country |
| Subdivision Name1: | Canada |
| Subdivision Type2: | Province |
| Subdivision Name2: | Ontario |
| Subdivision Type3: | Region |
| Subdivision Name3: | Eastern Ontario |
| Subdivision Type4: | Counties |
| Source1: | Sixth Depot Lake |
| Source1 Location: | Stone Mills, Lennox and Addington County |
| Source1 Coordinates: | 44.5842°N -76.9078°W |
| Source1 Elevation: | 192m (630feet) |
| Mouth: | Napanee River |
| Mouth Location: | South Frontenac, Frontenac County |
| Mouth Coordinates: | 44.4614°N -76.7617°W |
| Mouth Elevation: | 141m (463feet) |
| River System: | Great Lakes Basin |
Depot Creek is a river in Frontenac County and Lennox and Addington County in Eastern Ontario, Canada.[1] It is in the Great Lakes Basin and is a left tributary of the Napanee River.
The creek begins at Sixth Depot Lake in Stone Mills, Lennox and Addington County, and flows northeast into Central Frontenac, Frontenac County and to Fifth Depot Lake, then turns southeast to Fourth Depot Lake, turns south, is crossed by the Canadian Pacific Railway main line and reaches Third Depot Lake. It exits Third Depot Lake controlled by a dam, heads southeast to Second Depot Lake, exits that lake controlled by a dam, continues southeast into South Frontenac and to First Depot Lake, heads south, flows through the community of Bellrock, and reaches its mouth at the Napanee River. The Napanee River flows to the Bay of Quinte on Lake Ontario.