| Official Name: | Depauw, Indiana |
| Settlement Type: | Census-designated place |
| Mapsize: | 150px |
| Pushpin Map: | USA Indiana Harrison County |
| Pushpin Label: | Depauw |
| Pushpin Map Caption: | Depauw's Location In Harrison County |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Indiana |
| Subdivision Type2: | County |
| Subdivision Name2: | Harrison |
| Subdivision Type3: | Township |
| Subdivision Name3: | Blue River, Spencer |
| Area Total Km2: | 4.10 |
| Population Est: | 120 |
| Pop Est As Of: | 2020 |
| Timezone: | EDT |
| Utc Offset: | -4:00 |
| Coordinates: | 38.3328°N -86.2217°W |
| Elevation Ft: | 666 |
| Postal Code Type: | ZIP code |
| Postal Code: | 47115 |
| Blank Name: | FIPS code |
| Blank Info: | 18-17794[1] |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2830404 |
Depauw is an unincorporated community in Blue River Township and Spencer Township, Harrison County, Indiana. The population of Depauw is officially unknown but is estimated to be 120 as of 2020 and is slowly decreasing.
Depauw was platted by Felician Henriott on April 8, 1884.[2] According to one source, the community may be named for Washington C. DePauw.[3] Violent tornadoes that were recorded in Depauw include one on April 3, 1903, two on April 3, 1974, one on April 5, 1985, and one on June 2, 1990. On April 3, 1974, at around 3:20 PM, an F5 tornado hit Depauw, leaving some of the mobile homes and houses completely demolished. This tornado had formed near New Boston, IN. It kept heading east passing just west of Frenchtown, IN and then the tornado hit Depauw. Many of the Depauw locals who didn't have a basement quickly rushed to people's homes that did have one. The tornado went through Depauw and then it headed northeast towards Palmyra, IN after Depauw. The tornado killed 6 people and injured 76 people in the 68 miles (110 km) it was on the ground. The Depauw tornado was 1.6 miles (2.5 km) wide and was the first of many other F5 tornadoes that were to form on that same day in the midwest. The series of tornadoes that occurred on that day was part of what was known as the 1974 Super Outbreak.[4]
Depauw is located in northwest Harrison County.