Deoxycytidine diphosphate explained

Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP .

2'-Deoxycytidine diphosphate is abbreviated as dCDP.^[1]

Synthesis of cytidine nucleotides

Deoxycytidine diphosphate is synthesized through the oxidation-reduction reaction of cytidine 5'-diphosphocholine which is catalyzed by the presence of ribonucleoside-diphosphate reductase.^[2] Additionally, ribonucleoside-diphosphate reductase is capable of binding and catalyzing both the formation of deoxyribonucleotides from ribonucleotide.^[3]

See also

• DNA
• Cofactor
• Cytosine

References

1. https://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?mode=&index=108353 MeSH term
2. Kandeel . Mahmoud . Al-Taher . Abdulla . 2020-11-01 . Metabolic drug targets of the cytosine metabolism pathways in the dromedary camel (Camelus dromedarius) and blood parasite Trypanosoma evansi . Tropical Animal Health and Production . en . 52 . 6 . 3337–3358 . 10.1007/s11250-020-02366-8 . 32926292 . 221722974 . 1573-7438.
3. Torrents . Eduard . 2014 . Ribonucleotide reductases: essential enzymes for bacterial life . Frontiers in Cellular and Infection Microbiology . 4 . 52 . 10.3389/fcimb.2014.00052 . 24809024 . 4009431 . 2235-2988. free .

Further reading

• Kennedy, Eugene P.. Louise Fencil Borkenhagen. Sylvia Wagner Smith. Possible Metabolic Functions of Deoxycytidine Diphosphate Choline and Deoxycytidine Diphosphate Ethanolamine. Journal of Biological Chemistry. 1959. 234. 8. 1998–2000. 10.1016/S0021-9258(18)69855-2. 13673002. free.
• Reichard, Peter. Enzymatic Synthesis of Deoxyribonucleotides: I. FORMATION OF DEOXYCYTIDINE DIPHOSPHATE FROM CYTIDINE DIPHOSPHATE WITH ENZYMES FROM ESCHERICHIA COLI. Journal of Biological Chemistry. 1962. 237. 3513–3519. 10.1016/S0021-9258(19)70849-7. 13973714. free. .