Deoxycytidine deaminase explained

deoxycytidine deaminase
Ec Number:	3.5.4.5
Cas Number:	37259-56-6
Go Code:	0047844

In enzymology, a deoxycytidine deaminase is an enzyme that catalyzes the chemical reaction

deoxycytidine + H₂O

\rightleftharpoons deoxyuridine + NH₃

Thus, the two substrates of this enzyme are deoxycytidine and H₂O, whereas its two products are deoxyuridine and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is cytidine/2'-deoxycytidine aminohydrolase. This enzyme participates in pyrimidine metabolism. As every deoxycytidine deaminase is also a cytidine deaminase, they share the same EC number. The recommended name assigned by the IUBMB is cytidine deaminase.^[1]

References

• Cohen SS . Studies on controlling mechanisms in the metabolism of virus-infected bacteria . Cold Spring Harbor Symposia on Quantitative Biology . 18 . 221–35 . 1953 . 13168989 . 10.1101/sqb.1953.018.01.033.

Notes and References

1. Web site: BRENDA: Information on EC 3.5.4.5 - cytidine deaminase .