Dennie–Morgan fold explained

Dennie–Morgan fold
Synonyms:Morgan's line, Dennie's sign[1] [2]

A Dennie–Morgan fold, also known as a Dennie–Morgan line or an infraorbital fold, is a fold or line in the skin below the lower eyelid. It can simply be an ethnic/genetic trait,[3] but was found in one study to occur in 25% of patients with atopic dermatitis.[4] The presence of Dennie–Morgan folds can be used as a diagnostic marker for allergy,[5] [6] with a sensitivity of 78% and specificity of 76% for atopic dermatitis according to one study,[7] although another study found them to be of diagnostic significance in atopic dermatitis.[8] The condition was described by Charles Clayton Dennie and David B. Morgan in 1948. [9] [10]

The pathophysiology of this sign is not clear. One proposed mechanism is that continuous spasm of the superior tarsal muscle and skin edema could be due to hypoxia from poor circulation.[4]

A Dennie–Morgan fold should not be confused with an "allergic shiner", which is a purple-gray discoloration with associated fullness beneath the lower eyelid. This is related to the accumulation of blood and other fluid in the infraorbital groove resulting from nasal congestion.[4]

See also

Notes and References

  1. CTMA 2019: Compendium of therapeutics for minor ailments (2018). Ottawa, Ontario: Canadian Pharmacists Association.
  2. Yen . Angela . Sanchez . Ramon . Oblender . Melanie . Raimer . Sharon . Leukemia cutis: Darier's sign in a neonate with acute lymphoblastic leukemia . Journal of the American Academy of Dermatology . February 1996 . 34 . 2 . 375–378 . 10.1016/S0190-9622(07)80012-0. 8655730 .
  3. Williams HC, Pembroke AC . Infraorbital crease, ethnic group, and atopic dermatitis . Archives of Dermatology . 132 . 1 . 51–4 . January 1996 . 8546483 . 10.1001/archderm.1996.03890250061010 .
  4. Blanc S, Bourrier T, Albertini M, Chiaverini C, Giovannini-Chami L . Dennie-Morgan fold plus dark circles: suspect atopy at first sight . The Journal of Pediatrics . 166 . 6 . 1541 . June 2015 . 25890677 . 10.1016/j.jpeds.2015.03.033 .
  5. Morgan DB . A suggestive sign of allergy . Archives of Dermatology and Syphilology . 57 . 6 . 1050 . June 1948 . 18098747 . 10.1001/archderm.1948.01520190129018 .
  6. Uehara M . Infraorbital fold in atopic dermatitis . Archives of Dermatology . 117 . 10 . 627–9 . October 1981 . 7283456 . 10.1001/archderm.1981.01650100029022 .
  7. Schram ME, Leeflang MM, DEN Ottolander JP, Spuls PI, Bos JD . Validation and refinement of the Millennium Criteria for atopic dermatitis . The Journal of Dermatology . 38 . 9 . 850–8 . September 2011 . 21453318 . 10.1111/j.1346-8138.2011.01202.x . 26399856 .
  8. Mevorah B, Frenk E, Wietlisbach V, Carrel CF . Minor clinical features of atopic dermatitis. Evaluation of their diagnostic significance . Dermatologica . 177 . 6 . 360–4 . 1988 . 3234581 . 10.1159/000248607 .
  9. Web site: I Thought the Lines Around My Eyes Were Age-Related. They Were Actually Dennie-Morgan Lines . 12 February 2021 .
  10. A suggestive sign of allergy . 18098747 . 1948 . MORGAN DB . Archives of Dermatology and Syphilology . 57 . 6 . 1050 . 10.1001/archderm.1948.01520190129018 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dennie–Morgan fold".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.