| Honorific-Prefix: | The Most Excellent |
| Demetrio Larena | |
| Term Start: | November 5, 1898 |
| Term End: | April 30, 1901 |
| Predecessor: | (post made) |
| Successor: | Antonio Jayme (as Civil Vice-Governor) |
| Office: | Vice-President of the Republic of Negros |
| Term Start1: | 1901 |
| Term End1: | 1906 |
| Predecessor1: | (position last held by Antonio Ferrer, as Gobernadorcillo) |
| Successor1: | Hermenegildo Villanueva |
| Order1: | 1st |
| Office1: | Governor of Negros Oriental |
Demetrio Larena was a political hero and former governor of Negros Oriental (East Negros), a province on Negros Island in the Philippines. He was the vice-president of the Republic of Negros and eventually the governor of Negros Oriental from 1901 until 1906. Larena was instrumental in the establishment of Silliman University in Dumaguete. When Dr. David Hibbard came to the Philippines to scout for a good location of the school that the Presbyterian Board of Foreign Missions wanted to be founded, Dumaguete was not one of the places originally contemplated. The places that were considered as prospects for the school's location were Iloilo, Cebu and Zamboanga.[1] But due in part to Larena's accommodating gesture and Dumaguete's natural environment at that time, Hibbard decided that the best place to establish the school would be in Dumaguete.