Deltex e3 ubiquitin ligase 3 explained

Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene.^[1] It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c.^[2] DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.

Function

DTX3 functions as an E3 ubiquitin ligase.^[3] Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.

Further reading

• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA . The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity . J. Biol. Chem. . 278 . 24 . 21930–7 . 2003 . 12670957 . 10.1074/jbc.M301157200 . free .

Notes and References

1. Web site: Entrez Gene: Deltex E3 ubiquitin ligase 3. 2016-09-26.
2. Scalia . Pierluigi . Williams . Stephen J. . Suma . Antonio . Carnevale . Vincenzo . 2023-06-21 . The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer . Cells . 12 . 13 . 1680 . 10.3390/cells12131680 . free . 2073-4409 . 37443713. 10340142 .
3. Takeyama . Kunihiko . Aguiar . Ricardo C. T. . Gu . Liqun . He . Chunyan . Freeman . Gordon J. . Kutok . Jeffery L. . Aster . Jon C. . Shipp . Margaret A. . 2003-06-13 . The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity . The Journal of Biological Chemistry . 278 . 24 . 21930–21937 . 10.1074/jbc.M301157200 . free . 0021-9258 . 12670957.