Delta-like 1 explained

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.^[1]

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.^[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2^{[2] [3] [4]}

References

Further reading

• Watt FM . The stem cell compartment in human interfollicular epidermis . J. Dermatol. Sci. . 28 . 3 . 173–80 . 2002 . 11912004 . 10.1016/S0923-1811(02)00003-8 .
• Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ . Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear . Mech. Dev. . 78 . 1–2 . 159–63 . 1999 . 9858718 . 10.1016/S0925-4773(98)00165-8 . 9675950 . free .
• Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C . Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation . Dev. Biol. . 204 . 2 . 420–31 . 1999 . 9882480 . 10.1006/dbio.1998.9092 . free .
• Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S . Human Ligands of the Notch Receptor . Am. J. Pathol. . 154 . 3 . 785–94 . 1999 . 10079256 . 1866435 . 10.1016/S0002-9440(10)65325-4 .
• Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A . Expression of the mouse Delta1 gene during organogenesis and fetal development . Mech. Dev. . 84 . 1–2 . 165–8 . 1999 . 10473134 . 10.1016/S0925-4773(99)00065-9 . 15047523 . free .
• Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J . Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear . Mech. Dev. . 84 . 1–2 . 169–72 . 1999 . 10473135 . 10.1016/S0925-4773(99)00066-0 . 17955906 . free .
• Han W, Ye Q, Moore MA . A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells . Blood . 95 . 5 . 1616–25 . 2000 . 10688816 . 10.1182/blood.V95.5.1616.005k31_1616_1625.
• Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H . Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 . Mol. Cell. Biol. . 20 . 18 . 6913–22 . 2000 . 10958687 . 88767 . 10.1128/MCB.20.18.6913-6922.2000 .
• Shimizu K, Chiba S, Saito T, Kumano K, Hirai H . Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors . Biochem. Biophys. Res. Commun. . 276 . 1 . 385–9 . 2000 . 11006133 . 10.1006/bbrc.2000.3469 .
• Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L . Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation . J. Exp. Med. . 194 . 7 . 991–1002 . 2001 . 11581320 . 2193482 . 10.1084/jem.194.7.991 .
• Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H . Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain . EMBO J. . 21 . 3 . 294–302 . 2002 . 11823422 . 125840 . 10.1093/emboj/21.3.294 .
• Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS . Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe . J. Biol. Chem. . 277 . 33 . 29945–52 . 2002 . 12036964 . 10.1074/jbc.M204445200 . free .
• Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K . The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway . J. Biol. Chem. . 277 . 33 . 29399–405 . 2002 . 12050162 . 10.1074/jbc.M203727200 . free .
• Ohishi K, Varnum-Finney B, Bernstein ID . Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells . J. Clin. Invest. . 110 . 8 . 1165–74 . 2002 . 12393852 . 150801 . 10.1172/JCI16167 .
• Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J . A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 17119–24 . 2003 . 12482954 . 139279 . 10.1073/pnas.252624099 . free .
• Tohda S, Murata-Ohsawa M, Sakano S, Nara N . Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines . Int. J. Oncol. . 22 . 5 . 1073–9 . 2003 . 12684674 . 10.3892/ijo.22.5.1073 .
• Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F . The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase . Proc. Natl. Acad. Sci. U.S.A. . 100 . 13 . 7638–43 . 2003 . 12794186 . 164639 . 10.1073/pnas.1230693100 . 2003PNAS..100.7638S . free .
• LaVoie MJ, Selkoe DJ . The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments . J. Biol. Chem. . 278 . 36 . 34427–37 . 2003 . 12826675 . 10.1074/jbc.M302659200 . free .

Notes and References

1. Web site: Entrez Gene: DLL1 delta-like 1 (Drosophila).
2. Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H . Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation . J. Biol. Chem. . 276 . 28 . 25753–8 . July 2001 . 11346656 . 10.1074/jbc.M103473200 . free .
3. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S . Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane . Cell . 90 . 2 . 281–91 . July 1997 . 9244302 . 10.1016/s0092-8674(00)80336-0. 16544864 . free .
4. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H . Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 . Mol. Cell. Biol. . 20 . 18 . 6913–22 . September 2000 . 10958687 . 88767 . 10.1128/mcb.20.18.6913-6922.2000.