Deleted in lung and esophageal cancer 1 explained

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene.^[1]

Function

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].

Further reading

• Kwong J, Lee JY, Wong KK, Zhou X, Wong DT, Lo KW, Welch WR, Berkowitz RS, Mok SC . Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer . Neoplasia . 8 . 4 . 268–78 . April 2006 . 16756719 . 1600675 . 10.1593/neo.05502 .
• Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW . Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma . Genes Chromosomes Cancer . 46 . 2 . 171–80 . February 2007 . 17099870 . 10.1002/gcc.20398 . 45238991 .
• Qiu GH, Salto-Tellez M, Ross JA, Yeo W, Cui Y, Wheelhouse N, Chen GG, Harrison D, Lai P, Tao Q, Hooi SC . The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle . J. Hepatol. . 48 . 3 . 433–41 . March 2008 . 18191269 . 10.1016/j.jhep.2007.11.015 .
• Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR . DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma . Br. J. Cancer . 99 . 2 . 375–82 . July 2008 . 18594535 . 2480971 . 10.1038/sj.bjc.6604452 .
• Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, Goh HK, Rha SY, Tian L, Chan AT, Sung JJ, Tao Q . DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers . Br. J. Cancer . 100 . 4 . 663–9 . February 2009 . 19156137 . 2653732 . 10.1038/sj.bjc.6604888 .
• Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P . Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project . Cancer Res. . 69 . 7 . 2956–65 . April 2009 . 19339270 . 10.1158/0008-5472.CAN-08-2604 . 2318/104855 . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Al Sarakbi W, Reefy S, Jiang WG, Roberts T, Newbold RF, Mokbel K . Evidence of a tumour suppressor function for DLEC1 in human breast cancer . Anticancer Res. . 30 . 4 . 1079–82 . April 2010 . 20530412 .
• Zhang Y, Miao Y, Yi J, Wang R, Chen L . Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer . Clin Lung Cancer . 11 . 4 . 264–70 . July 2010 . 20630829 . 10.3816/CLC.2010.n.034 .

Notes and References

1. Web site: Entrez Gene: Deleted in lung and esophageal cancer 1. 2018-04-05.