Delayed gadolinium-enhanced magnetic resonance imaging of cartilage explained

Delayed gadolinium-enhanced magnetic resonance imaging of cartilage
Purpose:	measures relative proteoglycan content of articular cartilage

Delayed gadolinium-enhanced magnetic resonance imaging of cartilage or dGEMRIC measures the fixed-charge density and relative proteoglycan content of articular cartilage using the spin-lattice relaxation time or T1 relaxation time.^[1] Current research is investigating the clinical application of dGEMRIC as a quantitative tool for monitoring cartilage function in diseased or repair cartilage.^[2]

External links

• The Impact of the Relaxivity Definition on the Quantitative Measurement of Glycosaminoglycans in Cartilage by MRI dGEMRIC Method
• Delayed Gadolinium-enhanced MR Imaging of Articular Cartilage: Three-dimensional T1 Mapping with Variable Flip Angles and B1 Correction
• Toward Imaging Biomarkers for Glycosaminoglycans
• Longitudinal Evaluation of Cartilage Composition of Matrix-Associated Autologous Chondrocyte Transplants with 3-T Delayed Gadolinium-Enhanced MRI of Cartilage
• Association between findings on delayed gadolinium-enhanced magnetic resonance imaging of cartilage and future knee osteoarthritis
• Delayed Gadolinium-enhanced MR to Determine Glycosaminoglycan Concentration in Reparative Cartilage after Autologous Chondrocyte Implantation: Preliminary Results
• Glycosaminoglycan Distribution in Cartilage as Determined by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC): Potential Clinical Applications

Notes and References

1. Bashir. A . Gray, ML . Boutin, RD . Burstein, D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging.. Radiology. Nov 1997. 205. 2. 551–8. 9356644. 10.1148/radiology.205.2.9356644.
2. Siversson. C . Tiderius, CJ . Neuman, P . Dahlberg, L . Svensson, J. Repeatability of T1-quantification in dGEMRIC for three different acquisition techniques: two-dimensional inversion recovery, three-dimensional look locker, and three-dimensional variable flip angle.. Journal of Magnetic Resonance Imaging. May 2010. 31. 5. 1203–9. 20432357. 10.1002/jmri.22159. 34258524 . free.