| Official Name: | Deh-e Shir Khan |
| Native Name: | ده شيرخان |
| Settlement Type: | village |
| Pushpin Map: | Iran |
| Mapsize: | 150px |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Name1: | Markazi |
| Subdivision Type2: | County |
| Subdivision Name2: | Khondab |
| Subdivision Type3: | Bakhsh |
| Subdivision Name3: | Qareh Chay |
| Subdivision Type4: | Rural District |
| Subdivision Name4: | Javersiyan |
| Population As Of: | 2006 |
| Population Total: | 1,034 |
| Population Density Km2: | auto |
| Timezone: | IRST |
| Utc Offset: | +3:30 |
| Timezone Dst: | IRDT |
| Utc Offset Dst: | +4:30 |
| Coordinates: | 34.1639°N 49.3583°W |
Deh-e Shir Khan (Persian: ده شيرخان, also Romanized as Deh-e Shīr Khān and Deh Shīr Khān) is a village in Javersiyan Rural District, Qareh Chay District, Khondab County, Markazi Province, Iran. At the 2006 census, its population was 1,034, in 284 families.