Decoy receptor 1 explained

Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Further reading

• Kimberley FC, Screaton GR . Following a TRAIL: update on a ligand and its five receptors. . Cell Res. . 14 . 5 . 359–72 . 2005 . 15538968 . 10.1038/sj.cr.7290236 . free .
• Pan G, Ni J, Wei YF . An antagonist decoy receptor and a death domain-containing receptor for TRAIL. . Science . 277 . 5327 . 815–8 . 1997 . 9242610 . 10.1126/science.277.5327.815 . etal.
• Sheridan JP, Marsters SA, Pitti RM . Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. . Science . 277 . 5327 . 818–21 . 1997 . 9242611 . 10.1126/science.277.5327.818 . etal.
• Schneider P, Bodmer JL, Thome M . Characterization of two receptors for TRAIL. . FEBS Lett. . 416 . 3 . 329–34 . 1997 . 9373179 . 10.1016/S0014-5793(97)01231-3 . 83145771 . etal. free .
• Mongkolsapaya J, Cowper AE, Xu XN . Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL. . J. Immunol. . 160 . 1 . 3–6 . 1998 . 10.4049/jimmunol.160.1.3 . 9551946 . etal. free .
• Rieger J, Naumann U, Glaser T . APO2 ligand: a novel lethal weapon against malignant glioma? . FEBS Lett. . 427 . 1 . 124–8 . 1998 . 9613612 . 10.1016/S0014-5793(98)00409-8 . 5920531 . etal. free .
• Sheikh MS, Huang Y, Fernandez-Salas EA . The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. . Oncogene . 18 . 28 . 4153–9 . 1999 . 10435597 . 10.1038/sj.onc.1202763 . 22315889 . etal.
• Leverkus M, Walczak H, McLellan A . Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis. . Blood . 96 . 7 . 2628–31 . 2000 . 11001921 . 10.1182/blood.V96.7.2628. 42437707 . etal.
• Zhang XD, Nguyen T, Thomas WD . Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types. . FEBS Lett. . 482 . 3 . 193–9 . 2000 . 11024459 . 10.1016/S0014-5793(00)02042-1 . 12827383 . etal. free .
• Dörr J, Bechmann I, Waiczies S . Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. . J. Neurosci. . 22 . 4 . RC209 . 2002 . 11844843 . 6757573 . 10.1523/JNEUROSCI.22-04-j0001.2002. etal.
• Liao Q, Friess H, Kleeff J, Büchler MW . Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer. . Anticancer Res. . 21 . 5 . 3153–9 . 2002 . 11848467 .
• Bretz JD, Mezosi E, Giordano TJ . Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells. . Cell Death Differ. . 9 . 3 . 274–86 . 2002 . 11859410 . 10.1038/sj.cdd.4400965 . etal. free .
• Hueber A, Aduckathil S, Kociok N . Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells. . Graefes Arch. Clin. Exp. Ophthalmol. . 240 . 7 . 551–6 . 2002 . 12136286 . 10.1007/s00417-002-0487-6 . 10307168 . etal.
• Matysiak M, Jurewicz A, Jaskolski D, Selmaj K . TRAIL induces death of human oligodendrocytes isolated from adult brain. . Brain . 125 . Pt 11 . 2469–80 . 2002 . 12390973 . 10.1093/brain/awf254 . free .
• Ruiz de Almodóvar C, López-Rivas A, Redondo JM, Rodríguez A . Transcription initiation sites and promoter structure of the human TRAIL-R3 gene. . FEBS Lett. . 531 . 2 . 304–8 . 2002 . 12417331 . 10.1016/S0014-5793(02)03544-5 . 37720054 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ou D, Metzger DL, Wang X . TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction. . Diabetologia . 45 . 12 . 1678–88 . 2003 . 12488957 . 10.1007/s00125-002-0926-2 . etal. free .
• Hasel C, Dürr S, Rau B . In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. . Lab. Invest. . 83 . 6 . 825–36 . 2003 . 12808117 . 10.1097/01.lab.0000073126.56932.46. etal. free .

Notes and References

1. Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA . Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family . J Exp Med . 186 . 7 . 1165–70 . Nov 1997 . 9314565 . 2199077 . 10.1084/jem.186.7.1165 .
2. MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES . Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL . J Biol Chem . 272 . 41 . 25417–20 . Nov 1997 . 9325248 . 10.1074/jbc.272.41.25417 . free.
3. Web site: Entrez Gene: TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain.