| Official Name: | De Witt, New York |
| Settlement Type: | Census-designated place |
| Pushpin Map: | New York#USA |
| Pushpin Label: | De Witt |
| Coordinates: | 43.035°N -76.0678°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | New York |
| Subdivision Type2: | County |
| Subdivision Name2: | Onondaga |
| Subdivision Type3: | Town |
| Subdivision Name3: | DeWitt |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 6.50 |
| Area Land Sq Mi: | 6.49 |
| Area Water Sq Mi: | 0.02 |
| Area Total Km2: | 16.85 |
| Area Land Km2: | 16.80 |
| Area Water Km2: | 0.05 |
| Population As Of: | 2020 |
| Population Density Km2: | 669.54 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 473 |
| Postal Code Type: | ZIP Codes |
| Postal Code: | 13214 (De Witt) 13057 (East Syracuse) 13078 (Jamesville) 13224 (Syracuse) |
| Area Code: | 315/680 |
| Blank Name: | FIPS code |
| Blank Info: | 36-20467 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2806956 |
| Population Total: | 11247 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 1734.04 |
De Witt is a census-designated place (CDP) in the town of DeWitt, Onondaga County, New York, United States. It was first listed as a CDP prior to the 2020 census.
The CDP is in eastern Onondaga County, in the southern part of the town of DeWitt. It is bordered to the northwest by the city of Syracuse, to the north by the village of East Syracuse, and to the east and south by Interstate 481, which separates it from the rest of the town of DeWitt. East Genesee Street is the main road through the CDP, leading west 4miles to downtown Syracuse and east 3miles to Fayetteville. New York State Route 92 follows East Genesee Street within the De Witt CDP, while State Route 5 follows it in the eastern part of the CDP, before turning north to take Erie Boulevard toward downtown.
Le Moyne College is in the northwest corner of the CDP.