| Official Name: | De Soto, Mississippi |
| Pushpin Map: | Mississippi#USA |
| Pushpin Label: | De Soto |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Mississippi |
| Subdivision Type2: | County |
| Subdivision Name2: | Clarke |
| Unit Pref: | Imperial |
| Area Footnotes: | [1] |
| Area Total Km2: | 9.85 |
| Area Land Km2: | 9.79 |
| Area Water Km2: | 0.06 |
| Area Total Sq Mi: | 3.80 |
| Area Land Sq Mi: | 3.78 |
| Area Water Sq Mi: | 0.02 |
| Population As Of: | 2020 |
| Population Total: | 274 |
| Population Density Km2: | 27.98 |
| Population Density Sq Mi: | 72.47 |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 210 |
| Coordinates: | 31.9739°N -88.7133°W |
| Area Code: | 601 & 769 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 669157 |
De Soto is a census-designated place and unincorporated community in Clarke County, Mississippi, United States.
It was first named as a CDP in the 2020 Census which listed a population of 274.[2]
De Soto was named after Hernando de Soto.[3] De Soto was one of four principle towns established in Clarke County before the American Civil War. Established along the Chickasawhay River before the arrival of the Mobile and Ohio Railroad, construction of housing in De Soto may have started as early as 1845 and by 1858 churches were being erected. The town had a Post Office and two churches in 1900 when the population was 258.
A post office operated under the name De Soto from 1856 to 1978.[4]
At one point, De Soto was home to two sawmills, a drug store, a hotel, a blacksmith, and multiple general stores.[3]
Four sites in De Soto are listed on the National Register of Historic Places: the C. V. Akin House, the Carmichael House, the Cook-Sellers House, and the Covington House.
| White alone (NH) | 156 | 56.93% | |
| Black or African American alone (NH) | 108 | 39.42% | |
| Native American or Alaska Native alone (NH) | 0 | 0.00% | |
| Asian alone (NH) | 0 | 0.00% | |
| Pacific Islander alone (NH) | 0 | 0.00% | |
| Some Other Race alone (NH) | 1 | 0.36% | |
| Mixed Race or Multi-Racial (NH) | 5 | 1.82% | |
| Hispanic or Latino (any race) | 4 | 1.46% | |
| Total | 274 | 100.00% |