| De La Salle College | |
| Motto: | Latin: Indivisa Manent |
| Motto Translation: | Remain Undivided |
| Established: | 1905 |
| Type: | National School |
| Denomination: | Roman Catholic |
| Founder: | Rev. Br. Junianus Edward FSC |
| Director: | Rev. Br. Joseph Jeyakanthan FSC |
| City: | Mutwal, Colombo |
| Zipcode: | 01500 |
| Country: | Sri Lanka |
| Enrolment: | 1250 |
| Gender: | Boys |
| Grades: | 1 - 13 |
| Colours: | Red and blue |
| Affiliation: | De La Salle Brothers of the Christian Schools |
| Alumni: | Old LaSallians |
De La Salle College, Colombo is the only school in Sri Lanka dedicated to the Patron Saint of Christian Teachers St. John Baptist de la Salle, founder of the congregation of De La Salle Brothers of the Christian Schools in Latin: "Fratres Scholarum Christianarum"(FSC).
The college was inaugurated on 1 February 1905 by the LaSallian Brothers. Since then the school has been headed by many LaSallian Brothers as listed below.
| Junianus Edward | 1905/02/01 | Founder | |
| Bartholomew Paul | 1905/02/01 | First Director | |
| Edwin George | 1905/02/01 | First Sub Director | |
| Augustine Joseph | 1919 - 1923 | ||
| Alexander Basil | 1923 - 1925 | ||
| Luke Gregory | 1925 - 1931 | Silver Jubilee | |
| Claude Marie | 1932 - 1933 | ||
| Glastian Olivere | 1933 - 1935 | ||
| Wenceslaus | 1935 - 1937 | ||
| Caeser Albert | 1937 - 1938 | ||
| Emile OD Jeziza | 1938 - 1940 | ||
| Austin Anthony | 1940 - 1943 | ||
| Anselm Calixtus | 1943 - 1945 | ||
| Vincent Aloysius | 1945 - 1946 | ||
| Caeser Albert | 1946 - 1949 | Second Time | |
| Glastian Olivere | 1950 - 1951 | Second Time | |
| Austin Anthony | 1951 - 1952 | Second Time | |
| Stanislaus Norbert | 1952 - 1953 | Acting Director | |
| Hermenegild Joseph | 1953 - 1958 | Golden Jubilee | |
| Stephen Harding | 1958 - 1959 | ||
| Vincent Joseph | 1960 - 1961 | ||
| T Alphonsus | 1961 - 1966 | ||
| Edwin Ambrose | 1966 - 1969 | ||
| Thomas Philip | 1966 - 1967 | Acting Director | |
| Joseph Nicholas | 1969 - 1972 | ||
| A. Brenden | 1972 - 1976 | ||
| Eustace Bastian | 1976 - 1978 | ||
| Aloysius Stephen | 1978 - 1986 | Diamond Jubilee | |
| Placidus Fernando | 1986 - 1989 | ||
| Ignatius Warnakula | 1989 - 1992 | ||
| Eustace Bastian | 1992 - 1994 | Second Time | |
| Anil Fernando | 1994 - 1995 | Acting Director | |
| Ernest Tarcisius | 1995 - 2012 | Centennial Jubilee | |
| Newman Muthuthambi | 2013 – 2020 | OMI Priest | |
| Joseph Jeyakanthan | 2021 – up to now |
Rev Br Luke Gregory, introduced a house system, with four houses: Edward, Augustine, Luke and Hermenegild, each named after a De La Salle brother. This system is used for events such as inter-house sports and athletics.
The Mazenodian-LaSallian (The Battle of the DEs) was an annual cricket encounter between De Mazenod College, Kandana and De La Salle College, Mutwal in since 1955. It is known as The Battle of the DEs due to the names of the two schools.