Dazoxiben Explained

Dazoxiben is an orally active thromboxane synthase inhibitor.^[1] It has shown a significant clinical improvement in patients with Raynaud's syndrome.^[2]

Synthesis

One convenient synthesis starts with the O-chloroethyl ether of p-hydroxybenzamide and proceeds bydisplacement with imidazole to give 2. Hydrolysis of the amide function completes the synthesis of dazoxiben.

Notes and References

1. 10.1111/j.1365-2125.1983.tb02119.x . Belch . J. J. . Cormie . J. . Newman . P. . McLaren . M. . Barbenel . J. . Capell . H. . Leiberman . P. . Forbes . C. D. . Prentice . C. R. . Dazoxiben, a thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome: A double-blind trial . British Journal of Clinical Pharmacology . 15 Suppl 1 . Suppl 1 . 113S–116S . 1983 . 6337601 . 1427695.
2. 10.1111/j.1365-2125.1983.tb02119.x . Belch . J. J. . Cormie . J. . Newman . P. . McLaren . M. . Barbenel . J. . Capell . H. . Leiberman . P. . Forbes . C. D. . Prentice . C. R. . Dazoxiben, a thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome: A double-blind trial . British Journal of Clinical Pharmacology . 15 Suppl 1 . Suppl 1 . 113S–116S . 1983 . 6337601 . 1427695.