Dazopride Explained

Dazopride (AHR-5531) is an antiemetic and gastroprokinetic agent of the benzamide class which was never marketed.[1] [2] [3] [4] [5] It acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.[3] [4] [6] In addition to its gastrointestinal effects, dazopride facilitates learning and memory in mice.[7]

See also

Notes and References

  1. Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB . Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy . Cancer Chemotherapy and Pharmacology . 31 . 6 . 442–444 . 1993 . 8453682 . 10.1007/bf00685032 . 23122385 .
  2. Alphin RS, Proakis AG, Leonard CA, Smith WL, Dannenburg WN, Kinnier WJ, Johnson DN, Sancilio LF, Ward JW . 6 . Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility . Digestive Diseases and Sciences . 31 . 5 . 524–529 . May 1986 . 3698769 . 10.1007/bf01320319 . 6571531 .
  3. Costall B, Domeney AM, Gunning SJ, Kelly ME, Naylor RJ, Nohria V, Owera-Atepo JB, Simpson KM, Tan CC, Tattersall D . 6 . The action of dazopride to enhance gastric emptying and block emesis . Neuropharmacology . 26 . 7A . 669–677 . July 1987 . 3114664 . 10.1016/0028-3908(87)90227-9 . 25143512 .
  4. Costall B, Domeney AM, Naylor RJ, Tattersall FD . Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs . Neuropharmacology . 26 . 9 . 1321–1326 . September 1987 . 2890117 . 10.1016/0028-3908(87)90094-3 . 24621209 .
  5. Book: Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents . Chapman & Hall/CRC . Boca Raton . 1996 . 0-412-46630-9 .
  6. Villalón CM, den Boer MO, Heiligers JP, Saxena PR . Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig . British Journal of Pharmacology . 102 . 1 . 107–112 . January 1991 . 2043916 . 1917868 . 10.1111/j.1476-5381.1991.tb12140.x .
  7. Book: Montgomery SA, Halbreich U . Pharmacotherapy for mood, anxiety, and cognitive disorders . American Psychiatric Press . Washington, DC . 2000 . 0-88048-885-9 .

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