Dawn Bowdish Explained

Dawn M. E. Bowdish
Birth Date:21 May 1976
Birth Place:Canada
Fields:Biology
Immunology
Aging
Workplaces:McMaster University
Alma Mater:University of British Columbia, Vancouver
University of Oxford, England
Academic Advisors:Lori Burrows
Joe Lam
Robert E. W. Hancock
Siamon Gordon
Known For:Discovery of immunomodulatory properties of LL-37, MARCO signalling complex recognizing Mycobacterium tuberculosis, age-associated inflammation and its effects on pneumococcal pneumonia susceptibility and aging microbiome driving age-associated inflammation.

Dawn M. E. Bowdish, (born May 21, 1976) is a Canadian immunologist and currently a professor in the Department of Pathology and Molecular Medicine at McMaster University in Ontario, Canada. She is a Tier 2 Canada Research Chair in Aging & Immunity. She is known for several discoveries including the immunomodulatory properties of the antimicrobial peptide LL-37, how MARCO signalling complex recognizes Mycobacterium tuberculosis, age-associated inflammation and its effects on clearing pneumococcal pneumonia and how the aging gut microbiome drives age-associated inflammation.

Career and research

Training

Bowdish was born and raised in Hamilton, Ontario, Canada in 1976. In 1999, she graduated from the University of Guelph with an Honours Bachelor of Science in microbiology. Bowdish was a graduate student and obtained her PhD from the University of British Columbia between 2000 – 2005. There, under the supervision of Robert E. W. Hancock, she discovered the immunomodulatory role of the host defence peptide LL-37.[1] [2] [3] [4] As a Canadian Institute of Health Research Post-Doctoral Fellow, Bowdish worked at the University of Oxford from 2005-2008 under the supervision of Siamon Gordon in the Department of Pathology. It was during this time that she discovered the role of MARCO (macrophage receptor with collagenous structure) in recognizing and eliciting an immune response against trehalose dimycolate, the main immunogenic component in the outer membrane of Mycobacterium tuberculosis[5]

Career

In 2009, she joined the Department of Pathology & Molecular Medicine at McMaster University and was promoted to associate professor in 2014. In 2019, she was promoted to tenure professor in the same department. The Bowdish lab focuses primarily on the effects of aging on the immune system, specifically macrophages. Her lab has been able to elucidate a mechanistic explanation for how aging alters myeloid cells and how these cells increase susceptibility to pneumococcal pneumonia.[6] [7] [8] In 2017, the Bowdish lab demonstrated that age-associated gut microbe dysbiosis in mice increases age-associated inflammation.[9] Bowdish currently holds an h-index score of 38. Bowdish's published works have received much media attention[10] [11] [12] and continue to contribute more information regarding the interplay between the immune system, the gut microbiota, susceptibility to infection and aging.

Personal life

While attending post-secondary studies, Dawn was debating between a degree in Women's studies or Microbiology, but ultimately decided on Microbiology. Bowdish promotes social media use and encourages scientists to use these platforms as networking tools, to enhance interactions with the lay public and to promote diversity and equality in the sciences.

Fellowships and awards

Editorships

Leadership

Select publications

External links

Notes and References

  1. Bowdish D. M., Davidson D. J., Speert D. P., Hancock R. E. . 2004 . The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes . Journal of Immunology . 172 . 6. 3758–65 . 10.4049/jimmunol.172.6.3758 . 15004180 . free .
  2. Bowdish D.M., Davidson D. J., Lau Y.E., Lee K., Scott M. G., Hancock R. E. . 2005 . Impact of LL-37 on anti-infective immunity . Journal of Leukocyte Biology . 77 . 4. 451–9 . 10.1189/jlb.0704380 . 15569695 . free .
  3. Bowdish D.M., Davidson D.J., Hancock R.E. . 2005 . A re-evaluation of the role of host defence peptides in mammalian immunity . Current Protein & Peptide Science . 6 . 1. 35–51 . 10.2174/1389203053027494 . 15638767 .
  4. Bowdish D. M., Davidson D. J., Scott M. G., Hancock R. E. . 2005 . Immunomodulatory activities of small host defense peptides . Antimicrobial Agents and Chemotherapy . 49 . 5. 1727–32 . 10.1128/AAC.49.5.1727-1732.2005 . 15855488 . 1087655.
  5. Bowdish D.M., Sakamoto K., Kim M. J., Kroos M., Mukhopadhyay S., Leifer C. A., Tryggvason K., Gordon S., Russell D. G. . 2009 . MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis . PLOS Pathogens . 5 . 6. e1000474 . 10.1371/journal.ppat.1000474 . 19521507 . 2688075 . free .
  6. Verschoor C. P., Johnstone J., Loeb M., Bramson J. L., Bowdish D. M. . 2014 . Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling . Human Immunology . 75 . 12. 1192–6 . 10.1016/j.humimm.2014.10.004 . 25446401 .
  7. Verschoor C.P., Johnstone J., Millar J., Parsons R., Lelic A., Loeb M., Bramson J. L., Bowdish D. M. . 2014 . Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly . PLOS ONE . 9 . 8. e104522 . 10.1371/journal.pone.0104522 . 25105870 . 4126708. 2014PLoSO...9j4522V . free .
  8. Puchta A., Naidoo A., Verschoor C. P., Loukov D., Thevaranjan N., Mandur T. S., Nguyen P., Jordana M., Loeb M., Xing Z., Kobzik L., Larché M. J., Bowdish D. M. E. . 2016 . TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity . PLOS Pathogens . 12 . 1 . 1 . 10.1371/journal.ppat.1005368 . 26766566 . 4713203 . free .
  9. Thevaranjan N., Puchta A., Schulz C., Naidoo A., Szamosi J. C., Verschoor C. P., Loukov D., Schenck L. P., Jury J., Foley K. P., Schertzer J. D., Larché M. J., Davidson D. J., Verdú E. F., Surette M. G., Bowdish D. M. E. . 2017 . Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction . Cell Host & Microbe . 21 . 4. 455–466 . 10.1016/j.chom.2017.03.002 . 28407483 . 5392495.
  10. Web site: Gut microbes contribute to age-associated inflammation: Mouse study. EurekAlert!.
  11. Web site: Gut Microbes Contribute to Age-Associated Inflammation in Mice. The Scientist Magazine®.
  12. http://www.bowdish.ca/lab/wp-content/uploads/2016/01/529258d-1.pdf Immune cell goes awry with age

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