| Order: | 76th Doge of the Republic of Genoa |
| Term Start1: | 14 November 1587 |
| Term End1: | 14 November 1589 |
| Predecessor1: | Ambrogio Di Negro |
| Successor1: | Battista Negrone |
| Birth Date: | 1518 |
| Birth Place: | Genoa, Republic of Genoa |
| Death Date: | 1607 |
| Death Place: | Genoa, Republic of Genoa |
Davide Vacca (Genoa, 1518 - Genoa, 1607) was the 76th Doge of the Republic of Genoa.
A well-known notary and graduate in civil and canon law, Davide Vacca was one of the first members of the "Venerandum Collegium Dominorum Jurisperitorum et Judicum civitatis Januae". He had excellent relations with the Doria family and in particular friendly relations with the famous admiral Andrea Doria who favored the entry of his family into the Albergo of the Genoese nobility on the occasion of the state reform of 1528. His name was chosen by the Grand Council for the leadership of the Republic on 14 November 1587, the thirty-first in biennial succession and the seventy-sixth in republican history. Among the important events of Vacca's doge's mandate were the constant disagreements and contrasts with the neighboring Duchy of Savoy in territorial matters. He ended his government on 14 November 1589, which was presumably followed by the office of perpetual attorney and other representative duties. Vacca died in Genoa in 1607.