David W. Grainger Explained

David W. Grainger
Birth Date:11 June 1961
Birth Place:Boston, Massachusetts
Citizenship:American
Field:Biomedical Engineering
Work Institutions:University of Utah Distinguished Professor, Chair, Biomedical Engineering
Education:University of Utah, 1987 Ph.D., Pharmaceutical.[1] Dartmouth College, 1983 B.A., Engineering, Chemistry minor
Lewis and Clark High School, 1979, Valedictorian[2]
Known For:Scientific contributions in biomedical micro- and nanotechnology, drug delivery systems, and medical device innovation
Website:

David William Grainger is a distinguished professor and chair of the department of biomedical engineering and distinguished professor of pharmaceutics and pharmaceutical chemistry at the University of Utah. His research focuses on biomaterials, drug delivery, and medical device innovation.[3]

Personal life

David William Grainger III was born in Boston, Massachusetts, and grew up in Spokane, Washington. He graduated from Lewis and Clark High School in 1979 as valedictorian.

Education

Grainger graduated with a B.A. degree in engineering and minor in chemistry in 1983.[2] In 1987, Grainger completed his Ph.D. degree at the University of Utah in pharmaceutical chemistry in 1987 under National Academy member, Prof. Sung Wan Kim.[2] His dissertation work involved synthesis of heparinized block copolymers and analysis of their blood coagulation properties in vitro and in vivo.[4] He was awarded a postdoctoral fellowship from the Alexander von Humboldt Foundation to work with Prof. Helmut Ringsdorf at the University of Mainz, Germany.[1] This work produced new strategies for organizing two-dimensional protein structures on planar lipid films.[5]

Career and research

Grainger's early research focused on the failure of medical implants in the human body and the problems associated with blood coagulation and infection.[6] Grainger began his academic career as an assistant professor at the Oregon Graduate Institute.[2] [7] He moved to become associate professor in the department of chemistry at Colorado State University and was promoted to full professor there in 1999.[1] In 2006, Grainger was awarded the Inaugural George S. and Dolores Doré Eccles Presidential Endowed Chair and professor in the department of pharmaceutics and pharmaceutical chemistry, health sciences, at the University of Utah.[2] He chaired this department from 2006 to 2016, then became department chair of the department of biomedical engineering at the University of Utah, where he currently resides as a university distinguished professor.[6]

Grainger's research focuses mainly on biomaterials and drug delivery systems in biomedical engineering applications.

Drug delivery

Much of Grainger's current research is focused on two drug delivery device issues: Drug device integration,[8] and nanotoxicology;[9] however, his research portfolio is quite diverse.

His work in nanotoxicology (the study of the toxicity of nanomaterials) ranges from testing drug toxicity in vitro,[10] to investigation of infections caused by materials implanted in the body.[11] The issue of nanotoxicity in transportation of drug particles is also an area of his expertise.[12] Much of his work in this area focuses on finding the surface interactions at the drug-tissue, drug-material interface.

His research in drug device integration began with his work in pharmacology and nanomedicine. This moved into work in localized drug delivery devices to treat conditions like prophylaxis[13] and insights into infection caused by implanted materials.[14] Additional research includes: Extensive work to characterize the functions and applications of growth factor-β, specifically its implications in conditions including Arteriosclerosis and Thrombosis,[15] [16] [17] [18] diagnosis of coronary heart disease[19] and proliferation of human muscular tissue.[20]

Biomaterials

Some of Grainger's work with biomaterials is focused on surface modification,[21] patterning and analytical methods,[22] and ultrathin protein and polymer films.[23] [24] In a study of functionalized poly(ethylene glycol)-based bioassays, he helped discover a new surface chemistry which inhibits nonspecific biomolecular interactions and provides the capacity for specific immobilization of desired biomolecules.[21]

In another study involving surface chemistry, Grainger investigated organic thiol and bi-sulfide binding interactions with gold surfaces. It was common practice for self-assembled monolayer (SAM) systems to use sulfur anchor groups and gold surfaces, while the gold-sulfur bonding mechanisms had not yet been explored. The findings from this experiment showed the importance of selecting a proper solvent for SAM systems on gold surfaces[25]

External links

Notes and References

  1. Web site: Grainger . David . Faculty Profiles . University of Utah .
  2. Web site: Grainger . David . Profile . LinkedIn . April 25, 2019.
  3. Web site: Grainger . David . Personal Profile . University of Utah Biomedical Engineering .
  4. Grainger . David . Knutson . K . Kim . S . Feijen . J . Poly (dimethylsiloxane)-poly (ethylene oxide)-heparin block copolymers II: Surface characterization and in vitro assessments. . Journal of Biomedical Materials Research . 1990 . 24 . 4 . 403–31 . 10.1002/jbm.820240402 . 2347871 .
  5. Maloney . K . Grainger . D . Phase separated anionic domains in ternary mixed lipid monolayers at the air-water interface . Chemistry and Physics of Lipids . 1993 . 65 . 1 . 31–42 . 10.1016/0009-3084(93)90079-I . 8348675 .
  6. Web site: Newsletter . University of Utah College of Engineering .
  7. Yu . H . Grainger . D . Amphiphilic Thermosensitive N-isopropylacrylamide Terpolymer Hydrogels Prepared by Micellar Polymerization in Aqueous Media . Macromolecules . 1994 . 27 . 16 . 4554–4560. 10.1021/ma00094a019 . 1994MaMol..27.4554Y .
  8. 8. H.J. Busscher, V. Alt, H.C. van der Mei, P.H., Fagette, W. Zimmerli, T.F. Moriarty, J. Parvizi, G. Schmidmaier, M.J. Raschke, T. Gehrke, R. Bayston, L.M. Baddour, L.C. Winterton, R.O. Darouiche, D.W. Grainger, "A Trans-Atlantic Perspective on Stagnation in Clinical Translation of Antimicrobial Strategies for the Control of Biomaterial-Implant Associated Infection", ACS Biomaterials Sci Eng, vol. 5, pp. 402−406, (2019)
  9. 9. D.W. Grainger, Theme Editor, "Nanotoxicity in Drug Delivery", Adv. Drug Del. Rev., vol. 61, no. 6, (2009).
  10. Jones, C. F., & Grainger, D. W. In vitro assessments of nanomaterial toxicity. Advanced Drug Delivery Reviews, vol. 61, no. 6, pp. 438-456, (2009).
  11. Busscher, H. J., Mei, H. C., Subbiahdoss, G., Jutte, P. C., J. J. A. M. Van Den Dungen, Zaat, S. A., . . . Grainger, D. W. Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface. Science Translational Medicine, vol. 4, no. 153, (2012).
  12. D.W. Grainger, Theme Editor, "Nanotoxicity in Drug Delivery", Adv. Drug Del. Rev., vol. 61, no. 6, (2009).
  13. Wu, P., & Grainger, D. W. Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials, vol. 27, no. 11, pp. 2450-2467, (2006)
  14. H.J. Busscher, V. Alt, H.C. van der Mei, P.H., Fagette, W. Zimmerli, T.F. Moriarty, J. Parvizi, G. Schmidmaier, M.J. Raschke, T. Gehrke, R. Bayston, L.M. Baddour, L.C. Winterton, R.O. Darouiche, D.W. Grainger, "A Trans-Atlantic Perspective on Stagnation in Clinical Translation of Antimicrobial Strategies for the Control of Biomaterial-Implant Associated Infection", ACS Biomaterials Sci Eng, vol. 5, pp. 402−406, (2019)
  15. Grainger, D. Genetic control of the circulating concentration of transforming growth factor type beta1. Human Molecular Genetics, vol. 8, no. 1, pp. 93-97, (1999)
  16. Grainger, D. J., Kemp, P. R., Liu, A. C., Lawn, R. M., & Metcalfe, J. C. C. Genetic control of the circulating concentration of transforming growth factor type beta1. Nature, vol. 370, no. 6489, pp. 460-462, (1994)
  17. Grainger, D. J., Kemp, P. R., Metcalfe, J. C., Liu, A. C., Lawn, R. M., Williams, N. R., . . . Chauhan, A. The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis. Nature Medicine, vol. 1, no. 1, pp. 74-79, (1995)
  18. Grainger, D. J. Transforming Growth Factor β and Atherosclerosis: So Far, So Good for the Protective Cytokine Hypothesis. Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 3, pp. 399-404, (2004).
  19. 10. Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W., . . . Grainger, D. J. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nature Medicine, vol. 8, no. 12, pp. 1439-1445, (2002).
  20. Grainger, D., Kirschenlohr, H., Metcalfe, J., Weissberg, P., Wade, D., & Lawn, R. Proliferation of human smooth muscle cells promoted by lipoprotein(a). Science, vol. 260, no. 5114, pp. 1655-1658, (1993)
  21. Harbers, Gregory M., et al. "Functionalized Poly(Ethylene Glycol)-Based Bioassay Surface Chemistry That Facilitates Bio-Immobilization and Inhibits Nonspecific Protein, Bacterial, and Mammalian Cell Adhesion." Chemistry of Materials, vol. 19, no. 18, pp. 4405–4414 (2007).
  22. H. Takahashi, M. Dubey, K. Emoto, D.G. Castner, D.W. Grainger, "Imaging surface immobilization chemistry: correlation with cell patterning on non-adhesive hydrogel thin films", Adv. Funct. Mater., vol. 18, pp. 2079-2088. doi: 10.1002/adfm.200800105; PMCID: PMC2917816 NIHMSID: NIHMS187260. (2008).
  23. F. Sun and D.W. Grainger, "Ultrathin Self-Assembled Polymeric Films on Solid Surfaces. I. Synthesis and Characterization of Acrylate Copolymers Containing Alkyl Disulfide Side Chains", J. Polym. Sci. A, Polym. Chem, vol. 31, pp. 1729-1740 (1993)
  24. D.W. Grainger, "Synthetic Polymer Ultrathin Films for Modifying Surface Properties", Prog. Colloid Polym. Sci, vol. 103, pp. 243-250 (1997).
  25. Castner, David G. G, et al. "X-Ray Photoelectron Spectroscopy Sulfur 2p Study of Organic Thiol and Bisulfide Binding Interactions with Gold Surfaces." Langmuir, vol. 12, no. 21, pp. 5083–5086 (1996).

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