David Siderovski Explained

David Siderovski
Fields:Biochemistry
Pharmacology
Neuroscience
Medical education
Workplaces:Amgen Research Institute
University of North Carolina at Chapel Hill
West Virginia University
University of North Texas Health Science Center
Thesis Title:Human Immunodeficiency Virus Type-1 Trans-activator of Transcription (HIV-1 Tat)
Thesis Url:http://www.collectionscanada.gc.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ27724.pdf
Thesis Year:1997
Doctoral Advisor:Tak Wah Mak
Academic Advisors:Alfred G. Gilman
Robert J. Lefkowitz
Prizes:ASPET's John J. Abel Award in 2004

David Siderovski is a North American pharmacologist.[1] Since March 2020, Siderovski has been Chair of the HSC Department of Pharmacology & Neuroscience at the University of North Texas Health Science Center.[2] From 2012 to 2019, he was the E.J. Van Liere Medicine Professor and Chair of Physiology, Pharmacology & Neuroscience for the West Virginia University School of Medicine.[3]

Education

Siderovski attended Earl Haig Secondary School in North York, Ontario,[4] graduating in 1985.[5] In 1989, Siderovski graduated with a BSc from Queen's University in Kingston, Ontario.[6]

Siderovski began his PhD training at the University of Toronto in May 1989. During his fifth year of his PhD, he began full-time work as a research scientist in the Quantitative Biology Laboratory of the Amgen Research Institute, Toronto. He successfully defended his PhD thesis in November 1997.[7] He left the Amgen Research Institute in December 1998, having contributed to three patents as a co-inventor.[8] [9] [10]

Career

After completing his industrial postdoctoral position at the Amgen Research Institute in 1998,[11] Siderovski joined the faculty at the University of North Carolina at Chapel Hill as an assistant professor of pharmacology.[12] His earliest publications discuss the RGS protein superfamily,[13] [14] [15] [16] and determinations of their varied protein structures[17] [18] [19] and cellular functions.[20]

In 2004, Siderovski was named the top American Pharmacologist under 40 and awarded the John J. Abel Award by the American Society for Pharmacology and Experimental Therapeutics.[21] [22]

From 2006 to 2012, Siderovski was the Thomas J. Dark Basic Science Director of UNC's Medical Scientist Training Program.[23] In August 2014, Siderovski was appointed Director of the West Virginia University School of Medicine MD/PhD Scholars Program.[24] Siderovski has been serving as Editorial Board Member for the Journal of Biological Chemistry since 2012.[25]

Notes and References

  1. Web site: Abel Numbers. May 30, 2019. ASPET.org. November 21, 2019.
  2. News: Joy . William . New COVID-19 treatment has helped dozens in China, UNTHSC researchers say . wfaa.com . WFAA (ABC Channel 8 Dallas, TX) . 12 March 2020.
  3. News: One University Takes On the Opioid Crisis. Mcmurtrie. Beth. 2017-10-01. The Chronicle of Higher Education. 2019-11-21. en-US. 0009-5982.
  4. News: Gotlieb . Risha . School caters to bright kids . 27 December 2021 . The Toronto Star . Page NY5 . Torstar Syndication Services, a Division of Toronto Star Newspapers Limited . 9 Sep 1993 . en.
  5. News: Little . James . Two students who had 98.5 averages are both dubbed Metro's top students . 27 December 2021 . The Toronto Star . Torstar Syndication Services, a Division of Toronto Star Newspapers Limited . 5 July 1985. .
  6. Web site: Prince of Wales Prizes. Automatic Awards Open to All Upper Year Students. Queen's University. 11 August 2015. https://web.archive.org/web/20150924121248/http://www.queensu.ca/studentawards/automatic-awards-open-all-students. 24 September 2015. dead.
  7. Book: Siderovski, David Peter . Human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat): Random mutagenesis and interaction with PKR . 1997 . University of Toronto . 2015-08-04.
  8. Web site: Methods of modulating T-cell activation WO 1997041438 A1. 9 August 2015.
  9. Web site: Apoptosis-inducing factor CA 2352467 A1. 9 August 2015.
  10. Web site: Apoptosis-inducing factor CA 2352467 C. 9 August 2015.
  11. Web site: Can You Go Home Again? The Scientist Magazine. The Scientist. 2016-06-09.
  12. News: Lang . Leslie . UNC's Siderovski wins pharmacology award . 28 December 2021 . EurekAlert! . 25 March 2004 . en.
  13. Roush . Wade . Regulating G Protein Signaling . Science . 23 February 1996 . 271 . 5252 . 1056–1058 . 10.1126/science.271.5252.1056. 8599078 . 1996Sci...271.1056R . 83216123 .
  14. Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP . Molecular cloning and expression analysis of rat Rgs12 and Rgs14 . Biochem Biophys Res Commun . 233 . 3 . 770–7 . April 1997 . 9168931 . 10.1006/bbrc.1997.6537.
  15. Snow BE, Antonio L, Suggs S, Siderovski DP . Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene . Gene . 206 . 2 . 247–53 . January 1998 . 9469939 . 10.1016/s0378-1119(97)00593-3.
  16. Siderovski DP, Strockbine B, Behe CI . Whither goest the RGS proteins? . Crit Rev Biochem Mol Biol . 34 . 4 . 215–51 . 10517644 . 10.1080/10409239991209273 . 1999.
  17. Davis . Molly . Picture-perfect Proteins . Endeavors . 1 May 2007 .
  18. Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP . GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain . J Biol Chem . 273 . 28 . 17749–55 . July 1998 . 9651375 . 10.1074/jbc.273.28.17749. free .
  19. Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP . A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits . Proceedings of the National Academy of Sciences of the United States of America. 95 . 22 . 13307–12 . October 1998 . 9789084 . 23793. 10.1073/pnas.95.22.13307. 1998PNAS...9513307S . free .
  20. Ingi T, Krumins AM, Chidiac P, Brothers GM, Chung S, Snow BE, Barnes CA, Lanahan AA, Siderovski DP . Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity . J Neurosci . 18 . 18 . 7178–88 . September 1998 . 9736641 . 6793237. 10.1523/JNEUROSCI.18-18-07178.1998. etal.
  21. ASPET AWARD WINNERS FOR 2004 . The Pharmacologist . March 2004 . 46 . 1 . 3 . 27 December 2021.
  22. News: Lang . Leslie . UNC's Siderovski wins pharmacology award . 28 December 2021 . EurekAlert! . 25 March 2004 . en.
  23. Web site: Leadership . UNC MD-PhD Program (circa March 24, 2012) . Internet Archive Wayback Machine . 12 August 2015 . dead . https://web.archive.org/web/20120324031923/http://www.med.unc.edu/mdphd/fps/leadership . March 24, 2012 .
  24. Web site: Siderovski Chosen to Oversee M.D./PH.D. Scholars Program. School of Medicine > Home > News > Story. 11 August 2014 . WVU School of Medicine. 13 August 2015.
  25. Web site: JBC Editorial Board.

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