| Honorific-Prefix: | Hon. Professor |
| David Mwakyusa | |
| Honorific-Suffix: | MP |
| Office: | Member of Parliament for Rungwe West |
| Term Start: | November 2000 |
| Term End: | 2010 |
| Birth Date: | 9 November 1942 |
| Birth Place: | Tanganyika |
| Nationality: | Tanzanian |
| Party: | CCM |
| Spouse: | Margreth Mahundi Mwakyusa |
| Children: | Dr Sekela Mwakyusa,David Mwakyusa Jr, Lulu Mwakyusa, Lela Mwakyusa, Gida Mwakyusa |
| Alma Mater: | Makerere University University of Dar es Salaam |
| Profession: | Medical doctor |
David Homeli Mwakyusa (born 9 November 1942) is a Tanzanian CCM politician and Member of Parliament for Rungwe West constituency since 2000. He was Minister of Health from 2006 to 2010.[1]