| Birth Date: | 1931 6, df=y |
| Birth Place: | Birmingham, England |
| Death Place: | Appledore, Torridge (near Bideford), Devon, England |
| Field: | Biophysicist |
| Thesis Title: | X-ray analysis of haemoglobin : determination of phase angles by isomorphous substitution |
| Thesis Url: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596730 |
| Thesis Year: | 1958 |
| Work Institution: | Massachusetts Institute of Technology National Institutes of Health Imperial College London MRC Laboratory of Molecular Biology |
| Education: | Kingswood School |
| Alma Mater: | University of Cambridge (BA, PhD) |
| Doctoral Advisor: | Max Perutz[1] |
| Academic Advisors: | Alexander Rich |
| Notable Students: | Thomas A. Steitz Brian Matthews |
| Awards: | Wolf Prize in Chemistry (1987) |
| Known For: | Haemoglobin X-ray crystallography |
David Mervyn Blow [2] (27 June 1931 – 8 June 2004) was an influential British biophysicist. He was best known for the development of X-ray crystallography, a technique used to determine the molecular structures of tens of thousands of biological molecules. This has been extremely important to the pharmaceutical industry.[3]
Blow was born in Birmingham, England. He was educated at Kingswood School in Bath, Somerset and the University of Cambridge where he won a scholarship to Corpus Christi College, Cambridge. His PhD was awarded in 1958 for X-ray analysis of haemoglobin supervised by Max Perutz at the MRC Laboratory of Molecular Biology (LMB).[4] [5]
Following graduation from Cambridge, Blow spent two years at the Massachusetts Institute of Technology (MIT) and the National Institutes of Health (NIH) funded by the Fulbright Foundation
In 1954, he met Max Perutz;[6] they began to study a new technique wherein X-rays would be passed through a protein sample at the MRC Laboratory of Molecular Biology. This eventually led to the creation of a three-dimensional structure of haemoglobin.[7] Blow was appointed professor of biophysics at Imperial College London in 1977. His doctoral students include Richard Henderson,[8] [9] Paul Sigler, and Alice Vrielink.[10]
Blow was elected a Fellow of the Royal Society (FRS) in 1972. He was awarded the Wolf Prize in Chemistry in 1987.
Blow married Mavis Sears in 1955, and they had two children, a son Julian and a daughter Elizabeth. He died of lung cancer at the age of 72, in Appledore, Torridge (near Bideford), Devon.[11] [12]