David Altshuler (physician) explained

David Altshuler
Birth Name:David Matthew Altshuler
Birth Date:27 August 1964
Birth Place:Ithaca, New York
Thesis Title:Endogenous retinal activities that influence the development of rod photoreceptors in vitro
Thesis Url:http://search.proquest.com/docview/304096852
Thesis Year:1994
Doctoral Advisor:Connie Cepko
Known For:HapMap
Spouse:Jill Suttenberg Altshuler

David Matthew Altshuler (born August 27, 1964)[1] is a clinical endocrinologist and human geneticist. He is Executive Vice President, Global Research and Chief Scientific Officer at Vertex Pharmaceuticals.[2] Prior to joining Vertex in 2014, he was at the Broad Institute of Harvard and MIT,[3] and was a Professor of Genetics and Medicine at Harvard Medical School, and in the Department of Biology at Massachusetts Institute of Technology. He was also a faculty member in the Department of Molecular Biology, Center for Human Genetic Research, and the Diabetes Unit, all at Massachusetts General Hospital. He was one of four Founding Core Members of the Broad Institute, and served as the Institute's Deputy Director, Chief Academic Officer, and Director of the Program in Medical and Population Genetics.[4]

Education

Altshuler attended Commonwealth School in Boston, received his Bachelor of Science from Massachusetts Institute of Technology,[5] his Ph.D from Harvard University, and his M.D. from Harvard Medical School.[6] He completed his internship, residency, and clinical fellowship training at Massachusetts General Hospital.

Research

Altshuler's academic research focused on human genetic variation and its application to disease,[7] [8] [9] [10] using information from the Human Genome Project.[11] He has co-led the SNP Consortium, International HapMap Project,[12] [13] and 1000 Genomes Project[14] [15] [16] His research focused on the genetic basis of Type 2 Diabetes, and his laboratory contributed to mapping dozens of gene variants that are associated with risk of Type 2 Diabetes, lipid levels, myocardial infarction, rheumatoid arthritis, lupus, prostate cancer, and other disorders.

Awards and honors

Among his awards is election to the American Society for Clinical Investigation, the Association of American Physicians, and the Institute of Medicine. He is a member of the board of directors of the American Society of Human Genetics and was previously a member of the board of Vertex Pharmaceuticals. In 2011 he won the Curt Stern Award of the American Society of Human Genetics, and in 2012 the Outstanding Scientific Achievement Award of the American Diabetes Association. He is a member of the board of trustees of Becket Chimney Corners YMCA.

Notes and References

  1. Web site: Altshuler, David, 1964- . id.loc.gov . January 7, 2021.
  2. Web site: David Altshuler, M.D., Ph.D., Joins Vertex as Executive Vice President of Global Research and Chief Scientific Officer. Vertex. 30 March 2015.
  3. Web site: David Altshuler | Broad Institute of MIT and Harvard . 2012-03-27 . https://web.archive.org/web/20120327012941/http://www.broadinstitute.org/about/bios/bio-altshuler.html . dead .
  4. 10973253. 2000. Altshuler. D. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics. 26. 1. 76–80. Hirschhorn. J. N.. Klannemark. M. Lindgren. C. M.. Vohl. M. C.. Nemesh. J. Lane. C. R.. Schaffner. S. F.. Bolk. S. Brewer. C. Tuomi. T. Gaudet. D. Hudson. T. J.. Daly. M. Groop. L. Lander. E. S.. 10.1038/79216. 25842690.
  5. Web site: David Altshuler '86 | MIT Alumni Association's Infinite Connection . 2011-08-06 . https://web.archive.org/web/20110806164707/http://alum.mit.edu/news/AlumniProfiles/Archive/altshuler . dead .
  6. Web site: David Altshuler, M.D., Ph.D. | HMS Department of Genetics . 2012-03-08 . https://web.archive.org/web/20120308210843/http://genetics.med.harvard.edu/faculty/altshuler . dead .
  7. Altshuler . D. . Daly . M. J. . Lander . E. S. . Eric Lander. 10.1126/science.1156409 . Genetic Mapping in Human Disease . Science . 322 . 5903 . 881–888 . 2008 . 18988837 . 2694957 . 2008Sci...322..881A .
  8. Mootha . V. K. . Lindgren . C. M. . Eriksson . K. F. . Subramanian . A. . Sihag . S. . Lehar . J. . Puigserver . P. . Carlsson . E. . Ridderstråle . M. . Laurila . 10.1038/ng1180 . E. . Houstis . N. . Daly . M. J. . Patterson . N. . Mesirov . J. P. . Jill P. Mesirov. Golub . T. R. . Tamayo . P. . Spiegelman . B. . Lander . E. S. . Hirschhorn . J. N. . Altshuler . D. . Groop . L. C. . PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes . Nature Genetics . 34 . 3 . 267–273 . 2003 . 12808457. 13940856 .
  9. Lander . E. S. . Eric Lander. Altshuler . M. . Ireland . D. . Sklar . J. . Ardlie . P. . Patil . K. . Shaw . N. . Lane . C. R. . Lim . E. P. . Kalyanaraman . N. . Nemesh . J. . Ziaugra . L. . Friedland . L. . Rolfe . A. . Warrington . J. . Lipshutz . R. . Daley . G. Q. . Lander . E. S. . Characterization of single-nucleotide polymorphisms in coding regions of human genes . Nature Genetics . 22 . 3 . 231–238 . 10.1038/10290 . 1999 . 10391209 . 195213008 .
  10. De Bakker . P. I. W. . Yelensky . R. . Pe'Er . I. . Gabriel . S. B. . Daly . M. J. . Altshuler . D.. 10.1038/ng1669 . Efficiency and power in genetic association studies . Nature Genetics . 37 . 11 . 1217–1223 . 2005 . 16244653. 15464860 .
  11. Gabriel . S. B. . Schaffner . S. F. . Nguyen . H. . Moore . J. M. . Roy . J. . Blumenstiel . B. . Higgins . J. . Defelice . M. . Lochner . A. . Faggart . M. . Liu-Cordero . S. N. . Rotimi . C. . Adeyemo . A. . Cooper . R. . Ward . R. . Lander . E. S. . Daly . M. J. . Altshuler . D. . The Structure of Haplotype Blocks in the Human Genome . 10.1126/science.1069424 . Science . 296 . 5576 . 2225–2229 . 2002 . 12029063. 2002Sci...296.2225G . 10069634 . free .
  12. Gibbs . R. A. . Belmont . J. W. . Hardenbol . P. . Willis . T. D. . Yu . F. . Yang . H. . Ch'Ang . L. Y. . Huang . W. . 10.1038/nature02168 . Liu . B. . Shen . Y. . Tam . P. K. H. . Tsui . L. C. . Waye . M. M. Y. . Wong . J. T. F. . Zeng . C. . Zhang . Q. . Chee . M. S. . Galver . L. M. . Kruglyak . S. . Murray . S. S. . Oliphant . A. R. . Montpetit . A. . Hudson . T. J. . Chagnon . F. . Ferretti . V. . Leboeuf . M. . Phillips . M. S. . Verner . A. . Kwok . P. Y. . The International HapMap Project . Nature . 426 . 6968 . 789–796 . 2003 . 14685227 . 2003Natur.426..789G . 2027.42/62838 . 4387110 . free .
  13. Frazer . K. A. . Frazer . D. G. . Ballinger . D. R. . Cox . D. A. . Hinds . L. L. . Stuve . R. A. . Gibbs . J. W. . Belmont . A. . Boudreau . P. . Hardenbol . 10.1038/nature06258 . S. M. . Leal . S. . Pasternak . D. A. . Wheeler . T. D. . Willis . F. . Yu . H. . Yang . C. . Zeng . Y. . Gao . H. . Hu . W. . Hu . C. . Li . W. . Lin . S. . Liu . H. . Pan . X. . Tang . J. . Wang . W. . Wang . J. . Yu . B. . Zhang . Q. . Zhang . H. . 1 . A second generation human haplotype map of over 3.1 million SNPs . Nature . 449 . 7164 . 851–861 . 2007 . 17943122 . 2689609 . 2007Natur.449..851F .
  14. Gabriel . S. B. . Schaffner . S. F. . Nguyen . H. . Moore . J. M. . Roy . J. . Blumenstiel . B. . Higgins . J. . Defelice . M. . Lochner . A. . Faggart . M. . Liu-Cordero . S. N. . Rotimi . C. . Adeyemo . A. . Cooper . R. . Ward . R. . Lander . E. S. . Daly . M. J. . Altshuler . D. . The Structure of Haplotype Blocks in the Human Genome . 10.1126/science.1069424 . Science . 296 . 5576 . 2225–2229 . 2002 . 12029063. 2002Sci...296.2225G . 10069634 . free .
  15. Sachidanandam . R. . Weissman . D. . Schmidt . S. C. . Kakol . J. M. . Stein . L. D. . Lincoln Stein. Marth . G. . Sherry . S. . Mullikin . J. C. . Mortimore . B. J. . Willey . 10.1038/35057149 . D. L. . Hunt . S. E. . Cole . C. G. . Coggill . P. C. . Rice . C. M. . Ning . Z. . Rogers . J. . Bentley . D. R. . Kwok . P. Y. . Mardis . E. R. . Yeh . R. T. . Schultz . B. . Cook . L. . Davenport . R. . Dante . M. . Fulton . L. . Hillier . L. . Waterston . R. H. . McPherson . J. D. . Gilman . B. . Schaffner . S. . A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms . Nature . 409 . 6822 . 928–933 . 2001 . 11237013. 2001Natur.409..928S . free .
  16. https://scholar.google.co.uk/scholar?q=david+altshuler David Altshuler publications in Google Scholar

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