| Honorific-Prefix: | The Hon. |
| David MacKeen | |
| Order1: | 11th |
| Office1: | Lieutenant Governor of Nova Scotia |
| Predecessor1: | James Drummond McGregor |
| Successor1: | MacCallum Grant |
| Term Start1: | October 19, 1915 |
| Term End1: | November 13, 1916 |
| Monarch1: | George V |
| Governor General1: | the Duke of Connaught and Strathearn The Duke of Devonshire |
| Premier1: | George Henry Murray |
| Office2: | Senator for Cape Breton, Nova Scotia |
| Nominator2: | Mackenzie Bowell |
| Term Start2: | February 21, 1896 |
| Term End2: | October 15, 1915 |
| Constituency Mp3: | Cape Breton |
| Parliament3: | Canadian |
| Predecessor3: | Hector Francis McDougall |
| Successor3: | Charles Tupper |
| Term Start3: | February 22, 1887 |
| Term End3: | February 21, 1896 |
| Birth Date: | 20 September 1839 |
| Birth Place: | Mabou, Nova Scotia, Canada |
| Death Place: | Mabou, Nova Scotia, Canada |
| Nationality: | Canadian |
| Party: | Conservative[1] |
| Relations: | Henry Poole MacKeen |
| Occupation: | surveyor, mine manager |
| Profession: | politician |
David MacKeen (September 20, 1839 - November 13, 1916) was a Canadian surveyor, mine manager, politician, and the 11th Lieutenant Governor of Nova Scotia.
Born in Mabou, he was elected to the House of Commons of Canada for the riding of Cape Breton in the 1887 federal election. A Conservative, he was re-elected in the 1891 election. He was summoned to the Senate of Canada in 1896, representing the senatorial division of Cape Breton, Nova Scotia. He resigned in 1915 when he was appointed Lieutenant Governor of Nova Scotia. He died in office in 1916.[2]