David D. Spencer (1799 Bristol, Ontario County, New York - February 18, 1855 Ithaca, Tompkins County, New York) was an American editor and politician from New York.
In 1810, his family removed to Canandaigua, NY where he learned to be a printer. In 1820, he began publishing with Henry R. Stockton the Republican Chronicle in Ithaca, NY. In 1823, he married Melissa Lord, and they had five children. From 1828 to 1853, he published with Anson Spencer the Ithaca Chronicle.
He was a delegate to the 1839 Whig National Convention. He was one of the first three Inspectors of State Prisons elected on the Whig ticket in 1847 under the New York State Constitution of 1846, and drew the three-year term, being in office from 1848 to 1850.
His son Charles S. Spencer (b. 1824) was a member of the New York State Assembly in 1859 and 1874.