| David Campbell Humphreys | |
| Office: | Associate Justice of the Supreme Court of the District of Columbia |
| Term Start: | May 13, 1870 |
| Term End: | July 12, 1879 |
| Appointer: | Ulysses S. Grant |
| Predecessor: | George P. Fisher |
| Successor: | Charles Pinckney James |
| Office2: | Member of the Alabama House of Representatives |
| Term2: | 1843 1849 1853 1868 |
| Birth Name: | David Campbell Humphreys |
| Birth Date: | 9 November 1817 |
| Birth Place: | Morgan County, Alabama |
| Death Place: | Fairfax County, Virginia |
David Campbell Humphreys (November 9, 1817 – July 12, 1879) was an associate justice of the Supreme Court of the District of Columbia.
Born in Morgan County, Alabama, Humphreys began the practice of law in Madison County, Alabama. He was a member of the Alabama House of Representatives in 1843, 1849, 1853, and 1868. He was a planter and in private practice in Huntsville, Alabama from 1850 to 1861. During the American Civil War, he served in the Confederate States Army, rising to the rank of Colonel.
Humphreys was nominated by President Ulysses S. Grant on April 22, 1870, to an Associate Justice seat on the Supreme Court of the District of Columbia (now the United States District Court for the District of Columbia) vacated by Associate Justice George P. Fisher. He was confirmed by the United States Senate on May 10, 1870, and received his commission on May 13, 1870. His service terminated on July 2, 1879, due to his death in Fairfax County, Virginia.
In 1873, President Grant nominated Humphreys to a joint seat on the United States District Court for the Middle District of Alabama, the United States District Court for the Northern District of Alabama and the United States District Court for the Southern District of Alabama, in an effort to replace the increasingly unpopular Judge Richard Busteed with an Alabama native (Busteed was simultaneously nominated to take Humphreys' seat in the District of Columbia), but the nomination was returned by the Senate as irregular.
Humphreys' house in Huntsville, built in 1848, was listed on the National Register of Historic Places in 1977.