David C. Rubinsztein Explained

David Rubinsztein
Birth Name:David Chaim Rubinsztein
Fields:Autophagy
Neurodegenerative diseases
Workplaces:University of Cambridge
Cambridge Institute for Medical Research
Cambridge Drug Discovery Institute
Known For:autophagy and polyglutamine expansions
Alma Mater:University of Cape Town (MBChB, PhD)
Thesis Title:Monogenic hypercholesterolemia in South Africans: familial hypercholesterolemia in Indians and familial defective apolipoprotein B-100
Thesis Url:http://www.worldcat.org/oclc/890418932
Thesis Year:1993
Doctoral Advisor:Prof. D.R. van der Westhuyzen

David Chaim Rubinsztein (born 1963) FRS FMedSci is the Deputy Director of the Cambridge Institute of Medical Research (CIMR),[1] Professor of Molecular Neurogenetics at the University of Cambridge[2] and a UK Dementia Research Institute Professor.

Education

Rubinsztein completed his Bachelor of Medicine, Bachelor of Surgery (MB ChB) in 1986 and PhD in 1993 in the Medical Research Council/University of Cape Town Unit for the Cell Biology of Atherosclerosis. In 1993 he went to Cambridge as a senior registrar in Genetic Pathology.[3]

Career

In 1997, Rubinsztein acquired his Certificate of Completion of Specialist Training at the University of Cambridge. He was appointed to a Personal Readership at the University of Cambridge in 2003. In 2005, he was promoted to Professor of Molecular Neurogenetics at the University of Cambridge (personal chair). He has been an author on more than 400 scientific papers,[4] and was ranked as the 4th most cited European author from 2007 to 2013 in cell biology.[5] Rubinsztein has been invited to give talks at major international conferences, including Gordon Research Conferences and Keystone Symposia.[6] [7] [8]

Research

Rubinsztein has made major contributions to the field of neurodegeneration with his laboratory's discovery that autophagy regulates the levels of intracytoplasmic aggregate-prone proteins that cause many neurodegenerative diseases, including Huntington's, Parkinson's and Alzheimer's disease.[9] [10] [11] [12] [13] His lab has found that autophagy may be inhibited in various neurodegenerative diseases[14] and has elucidated the pathological consequences of autophagy compromise.[15] In addition his research has advanced the basic understanding of autophagy, identifying the plasma membrane as a source of autophagosome membrane[16] and characterising early events in autophagosome biogenesis,.[17] [18] [19] Furthermore, he studied how lysosomal positioning regulates autophagy.[20] His goal is to understand the links between these diseases and autophagy. He is currently focused on understanding how to induce autophagy in vivo to remove toxic proteins and avoid the development of neurodegenerative disease[21]

Honours and awards

Rubinsztein has won numerous awards including:

Notes and References

  1. Web site: Professor David C. Rubinsztein. University of Cambridge.
  2. Web site: Professor David Rubinsztein :: Cambridge Neuroscience. www.neuroscience.cam.ac.uk. 2018-01-08.
  3. http://f1000.com/prime/thefaculty/member/7810398887369674 F1000 Prime Faculty Member
  4. https://www.researchgate.net/profile/David_Rubinsztein/publications/ Research Gate
  5. Web site: Publication analysis 2007–2013, Cell Biology . 26 November 2015 . 4 March 2016 . https://web.archive.org/web/20160304050615/http://ki.se/sites/default/files/cellbiologystats.pdf . dead .
  6. Web site: Centre for Science and Policy. University of Cambridge.
  7. Renna. M.. Jimenez-Sanchez. M.. Sarkar. S.. Rubinsztein. D. C.. Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases. Journal of Biological Chemistry. 285. 15. 2010. 11061–11067. 0021-9258. 10.1074/jbc.R109.072181. 20147746. 2856980. free .
  8. Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases. The Journal of Biological Chemistry. 2010 . 20147746 . Renna . M. . Jimenez-Sanchez . M. . Sarkar . S. . Rubinsztein . D. C. . 285 . 15 . 11061–11067 . 10.1074/jbc.R109.072181 . 2856980 . free .
  9. 10.1038/nrd3802. 22935804. Autophagy modulation as a potential therapeutic target for diverse diseases. Nature Reviews Drug Discovery. 11. 9. 709–730. 2012. Rubinsztein . D. C. . 3518431.
  10. 10.1038/ng1362. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genetics. 36. 6. 585–595 . 2004. Ravikumar . B. . Rubinsztein . D. C. . 15146184. free.
  11. Web site: David Rubinsztein Interview - Special Topic of Autophagy - ScienceWatch.com. Analytics. Clarivate. archive.sciencewatch.com. 2018-01-08.
  12. 10.1038/nm1242. Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nature Medicine. 11. 6. 672–677 . 2005. Davies . J. E. . Rubinsztein . D. C. . 15864313. 13190118.
  13. 10.1038/nchembio883. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nature Chemical Biology. 3. 6. 331–338 . 2007. Sarkar . S. . Rubinsztein . D. C. . 17486044 . 2635561.
  14. 10.1083/jcb.201003122 . 20855506. α-Synuclein impairs macroautophagy: implications for Parkinson's disease. The Journal of Cell Biology. 190. 6. 1023–1037. 2010 . Winslow . A. R. . Rubinsztein . D. C.. 3101586.
  15. 10.1038/ng1591. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nature Genetics. 37. 7. 771–776. 2005. Ravikumar . B. . Rubinsztein . D. C. . 15980862. 7628772.
  16. 10.1038/ncb2078 . Plasma membrane contributes to the formation of pre-autophagosomal structures. Nature Cell Biology. 12. 8. 747–757. 2010 . Ravikumar . B. . Rubinsztein . D. C. . 20639872 . 2923063.
  17. 10.1016/j.cell.2011.06.023. Autophagosome precursor maturation requires homotypic fusion. Cell. 146. 2. 303–317. 2011 . Moreau . K. . Rubinsztein . D. C. . 21784250 . 3171170.
  18. 10.1016/j.cell.2013.08.044. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell. 154. 6. 1285–1299. 2013 . Puri . C. . Rubinsztein . D. C. . 24034251 . 3791395.
  19. 10.1016/j.molcel.2014.12.007. 25578879. 4306530. PI(5)P regulates autophagosome biogenesis. Molecular Cell. 57. 2. 219–234. 2015 . Vicinanza . M. . Rubinsztein . D. C..
  20. 10.1038/ncb2204. 21394080. 3071334. Lysosomal positioning coordinates cellular nutrient responses. Nature Cell Biology. 13. 4. 453–460. 2011 . Korolchuk . V. I. . Rubinsztein . D. C..
  21. News: Autophagy, a guardian against neurodegeneration - Part 2 - David Rubinsztein. 2013-11-27. SENS Research Foundation. 2018-01-08. en. 8 December 2015. https://web.archive.org/web/20151208133422/http://www.sens.org/videos/autophagy-guardian-against-neurodegeneration-part-2-david-rubinsztein/. dead.
  22. Web site: Professor David Rubinsztein FMedSci. acmedsci.ac.uk. Academy of Medical Sciences. London. Anon. 2004. 26 November 2015. 4 March 2016. https://web.archive.org/web/20160304053326/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/professor-david-rubinsztein/. dead.
  23. Web site: Wellcome Trust . 26 November 2015 . 2 October 2015 . https://web.archive.org/web/20151002023748/http://www.wellcome.ac.uk/Funding/Biomedical-science/Funded-projects/Awards-made/Wellcome-Fellows/WTD003260.htm . dead .
  24. Web site: Editor biographies. Nature.
  25. Web site: EMBO people: David C. Rubinsztein. people.embo.org.
  26. Web site: Funded People and Projects - Grant Funding | Wellcome.
  27. http://highlycited.com/ Thomson Reuters
  28. Web site: Labtimes: Publication Statistics: Cell Biology . 12 April 2016 . 29 July 2017 . https://web.archive.org/web/20170729050236/http://www.labtimes.org/labtimes/ranking/2015_05/index.lasso . dead .
  29. Web site: 2017 Award Winners. biochemistry.org. 12 April 2016. 4 June 2016. https://web.archive.org/web/20160604165124/http://www.biochemistry.org/Awards/2017Winners.aspx. dead.
  30. Web site: Professor David Rubinsztein FRS. royalsociety.org. London. Anon. 2017.
  31. Web site: Highly Cited Researchers - the Most Influential Scientific Minds.
  32. Web site: Highly Cited Researchers.
  33. Web site: Main Programme 212th Scientific Meeting of the Pathological Society of Great Britain & Ireland .
  34. Web site: Highly Cited Researchers.
  35. Web site: Highly Cited Researchers . 24 November 2021 . 24 November 2021 . https://web.archive.org/web/20211124080303/https://recognition.webofscience.com/awards/highly-cited/2021/ . dead .
  36. Web site: Member > Rubinsztein David.
  37. Web site: Highly Cited Researchers.
  38. Web site: Highly Cited Researchers.
  39. Web site: Scientific Research Award Recipients.

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