| David Clay Bramlette III | |
| Office: | Senior Judge of the United States District Court for the Southern District of Mississippi |
| Term Start: | March 20, 2006 |
| Office1: | Judge of the United States District Court for the Southern District of Mississippi |
| Term Start1: | November 25, 1991 |
| Term End1: | March 20, 2006 |
| Appointer1: | George H. W. Bush |
| Predecessor1: | Seat established by 104 Stat. 5089 |
| Successor1: | Halil Suleyman Ozerden |
| Birth Name: | David Clay Bramlette III |
| Birth Place: | Woodville, Mississippi, U.S. |
| Education: | Princeton University (BA) University of Mississippi (JD) |
David Clay Bramlette III (born November 27, 1939) is a senior United States district judge of the United States District Court for the Southern District of Mississippi.
Bramlette was born in Woodville, Mississippi. He received a Bachelor of Arts degree from Princeton University in 1962 and a Juris Doctor from the University of Mississippi Law School in 1965. He was in private practice in Natchez, Mississippi from 1965 to 1991. He was a special circuit judge of the Sixth Judicial District of Mississippi, from 1977 to 1979, a special chancery court judge, and a judge of the Adams County Court.
On July 26, 1991, Bramlette was nominated by President George H. W. Bush to a new seat on the United States District Court for the Southern District of Mississippi created by 104 Stat. 5089. He was confirmed by the United States Senate on November 21, 1991, and received his commission on November 25, 1991. He assumed senior status on March 20, 2006.