David Agus Explained

David Agus
Birth Date:29 January 1965
Alma Mater:Princeton University (1987)
University of Pennsylvania
Spouse:Amy Povich
Children:2

David B. Agus (pronounced as //ˈeɪgəs//) is an American physician, cancer researcher and author[1] who serves as a professor of medicine and engineering at the University of Southern California Keck School of Medicine and Viterbi School of Engineering[2] and the Founding Director and CEO of the Lawrence J. Ellison Institute for Transformative Medicine.[3] He is also the cofounder of several personalized medicine companies[4] [5] [6] and a contributor to CBS News on health topics.[7] He is also the author of four books.[8] [9] [10]

Agus's field of expertise is advanced cancer.[11] He has developed new cancer treatments with the aid of private foundations, as well as national agencies including the National Cancer Institute.[6] Agus has also served as chair of the Global Agenda Council on Genetics for the World Economic Forum,[12] and presently co-chairs the Global Health Security Consortium.

Early life and education

He graduated cum laude in molecular biology from Princeton University in 1987 and received his medical degree from the University of Pennsylvania Perelman School of Medicine in 1991.[13] He completed his residency training at Johns Hopkins Hospital and completed his oncology fellowship training at Memorial Sloan-Kettering Cancer Center in New York.[14] He spent two years at the National Institutes of Health as a Howard Hughes Medical Institute-NIH Research Scholar.[15] [16]

Career

Agus has had a long and varied career. At the Lawrence J. Ellison Institute for Transformative Medicine, he leads a team researching prevention and treatments for cancer.[17] He also maintains an oncology practice to apply his team's research discoveries to the patients under his care.[18] At the Memorial Sloan-Kettering Cancer Center in New York, he was an attending physician in the Department of Medical Oncology and head of the Laboratory of Tumor Biology. He was also assistant professor of medicine at Cornell University Medical Center.[19]

As director of the Spielberg Family Center for Applied Proteomics at Cedars-Sinai Medical Center in Los Angeles, he led a multidisciplinary team of researchers dedicated to the development and use of proteomic technologies to guide doctors in making health-care decisions tailored to individual needs. The center grew out of earlier clinical projects at Cedars-Sinai, where Agus served as an attending physician in oncology, which observed striking differences between the aggressiveness of prostate cancer in certain patients and their ability to respond to treatment.[20] [21]

Agus also formerly served as Director of the Louis Warschaw Prostate Cancer Center, and as an attending physician in the Department of Medicine, Division of Medical Oncology at Cedars-Sinai Medical Center. He was also an associate professor of medicine at the University of California, Los Angeles (UCLA).

He is presently a professor of Medicine and Engineering at the Keck School of Medicine of USC and the USC Viterbi School of Engineering and is the CEO and Founding Director of the Lawrence J. Ellison Institute for Transformative Medicine in Los Angeles and Oxford, England.[22] [23] Agus chairs the Global Agenda Council (GAC) on Genetics for the World Economic Forum,[24] and speaks regularly at TEDMED,[25] the Aspen Ideas Festival[26] and the World Economic Forum.[24]

Agus's research has focused on the use of technology to model cancer and on new treatments for cancer.[27] [28] He has published many scientific articles.[29]

Additional work and affiliations

He is a member of several scientific and medical societies, including the Council on Foreign Relations,[30] American Association for Cancer Research,[31] American College of Physicians,[32] American Society of Clinical Oncology.[33] Agus became a contributor for CBS News in 2013 and appears regularly on CBS This Morning and other CBS News platforms.[34]

He has founded and co-founded several companies including Oncology.com,[35] Navigenics (a personalized medicine company),[28] Applied Proteomics (together with Danny Hillis),[28] Sensei (wellness and lifestyle company, together with Larry Ellison),[36] Sensei Agriculture (an agriculture data and technology company together with Larry Ellison),[36] and Project Ronin (a cancer clinical intelligence company together with Larry Ellison).[37]

In 2021, Agus and the Ellison Institute launched Global Health Security Consortium (GHSC), a joint global effort with the Tony Blair Institute for Global Change and Sir John Bell and a team of scientists at the University of Oxford, focused on finding ways to track and treat COVID-19 and prevent future pandemics.[38] [39] GHSC is co-chaired by Agus with Sirs Tony Blair and John Bell. The group launched the OneShot campaign in October 2022 to build global digital health infrastructure and promote life course disease prevention programs.[40]

Agus co-chaired the Fortune Brainstorm Health conference from its inception in 2016 until 2022,[41] and the inaugural Time100 Health Summit in 2019.[42] He has hosted public health conversations with individuals like Bill Clinton,[43] Joe Biden,[44] and Albert Bourla, CEO of Pfizer.[45]

Writing career

Agus' first book, The End of Illness, was published in 2012 [46] is a New York Times best seller and international best seller and was the subject of a PBS series.[47] His books A Short Guide to a Long Life and The Lucky Years: How to Thrive in the Brave New World of Health[48] are also New York Times and international bestsellers.[49]

Agus occasionally collaborated with co-writer Kristen Loberg on the recommendation of his publisher Simon & Schuster.[50] On March 6, 2023, it was reported that the passages Loberg contributed to Agus' book The Book of Animal Secrets: Nature's Lessons for a Long and Happy Life contained heavy plagiarism.[51] Loberg issued a public apology and Agus stated that she misled him during the writing process by claiming to use antiplagiarism software.[52] Agus reviewed earlier works co-written by Loberg and informed Simon & Schuster that she had previously engaged in plagiarism.[53] Other publishers and physicians who had worked with Loberg, including Penguin Random House, Sanjay Gupta, and David Perlmutter, subsequently discovered further plagiarism by her.

The Book of Animal Secrets was initially set to be released on March 17, 2023, but sales were postponed at Agus' expense so that he could rewrite the book.[54] It is scheduled for release on December 5, 2023.[55]

Awards

Agus has received many honors and awards, including the Ellis Island Medal of Honor (2017),[56] American Cancer Society Physician Research Award,[57] [58] [59] a Clinical Scholar Award from the Sloan-Kettering Institute,[60] [61] a CaP CURE Young Investigator Award[59] and the American Society of Clinical Oncology Fellowship Award,[62] the HealthNetwork Foundation's Excellence Award,[62] and the 2009 Geoffrey Beene Foundation's Rock Stars of Science, as seen in GQ.[63] In 2009, he was selected to serve as a judge for the first Biotech Humanitarian Award.[64] [65]

Television show

Agus hosted a Paramount+ television show titled The Check Up with Dr. David Agus, which was broadcast starting in December 2022. In the show, Agus discussed different medical issues with celebrity guests who have experience with those health concerns.[66]

Perjeta clinical development

Agus and Mark Sliwkowski published the first studies with an antibody called 2C4 (pertuzumab or Perjeta), targeting the Her-2 molecule in breast and other cancers. This was the first drug that inhibited dimerization of receptors as its mechanism of action.[67] The mechanistic paper led to a phase 1 clinical trial led by Agus and further clinical studies in advanced breast cancer and other cancers.[68] [69] In 2012, the FDA gave the first of several approvals of Perjeta for combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. Perjeta was the first FDA approved drug that worked by inhibiting dimerization of receptors.[70] [71]

Personal life

Agus is married to Amy Joyce Povich, actress and daughter of syndicated television talk show host Maury Povich. Her stepmother, Connie Chung, is a former CBS News anchor. His grandfather, Rabbi Jacob B. Agus, was a theologian and the author of several books on Jewish history and philosophy. Agus has two children.[72]

Miscellaneous

Agus appears in the 2006 documentary Who Needs Sleep?.[73] PBS released a documentary on Agus' first book The End of Illness in 2016.[74] Agus delivered a TEDMED 2009 lecture on "A new strategy in the war on cancer", which is one of the most watched cancer talks on TED.com, and a TEDMED talk with Lance Armstrong in 2011.[75]

Agus was also the physician to Johnny Ramone during his battle with prostate cancer, and other prominent individuals.[76] He was on the board of directors of the Biden Cancer Initiative[77] until it was closed when Joe Biden ran for president,[78] Thrive Global, ImageneAI,[79] Project Ronin,[80] Sensei, Sensei Ag, the National Library of Israel[81] and the Peres Center for Peace and Innovation.[82] [83]

Bibliography

External links

Interviews, articles and podcasts

Notes and References

  1. Web site: David B. Agus, MD | Keck School of Medicine of USC. July 31, 2018 .
  2. Web site: David Agus. January 18, 2021. TEDMED.
  3. Web site: Ellison Institute for Transformative Medicine. January 18, 2021. en-US. January 25, 2021. https://web.archive.org/web/20210125011223/https://ellison.usc.edu/. dead.
  4. Web site: Hsieh. Nathaniel. October 15, 2012. Prof focuses on cancer prevention. January 18, 2021. Daily Trojan. en-US.
  5. Web site: Ellison-Agus' Sensei separating farm, retreat units. January 18, 2021. mauinews.com. en-US.
  6. Web site: Belvedere. Matthew J.. January 13, 2016. Top cancer doctor: Do these things to live longer. January 18, 2021. CNBC. en.
  7. Web site: Dr. David Agus. . October 9, 2014.
  8. Book: The End of Illness. October 16, 2012. 978-1-4516-1019-2. en. Agus. David B.. Simon and Schuster .
  9. Book: A Short Guide to a Long Life. December 30, 2014. 978-1-4767-3609-9. en. Agus. David B.. Simon and Schuster .
  10. Web site: David B. Agus, MD Keck School of Medicine of USC. July 31, 2018 . January 18, 2021. en-US.
  11. Web site: April 29, 2020. How a Los Angeles doctor got swept up in the White House's Covid-19 response. January 18, 2021. STAT. en-US.
  12. Web site: WVUToday Archive. January 18, 2021. wvutoday-archive.wvu.edu.
  13. Web site: 1990s Donors. Medical Alumni Donors. Penn Medicine Alumni. November 27, 2011. April 25, 2012. https://web.archive.org/web/20120425113503/http://alumni.med.upenn.edu/PartnersinGiving1990.php. dead.
  14. USC. "David B. Agus, M.D." Retrieved May 7, 2009.
  15. Web site: Beyond the Dome. February 9, 2021. www.hopkinsmedicine.org. en.
  16. Web site: July 10, 2010. David Agus, M.D. Profile at UCLA. dead. https://web.archive.org/web/20100710131128/http://dgsom.healthsciences.ucla.edu/institution/personnel?personnel_id=66398. July 10, 2010. February 9, 2021.
  17. Web site: David Agus, M.D. – Ellison Institute for Transformative Medicine. February 16, 2021. en-US. April 16, 2021. https://web.archive.org/web/20210416065929/https://ellison.usc.edu/portfolio/davidagus/. dead.
  18. Web site: Dr. David B. Agus, MD. live. https://web.archive.org/web/20160825094717/http://health.usnews.com:80/doctors/david-agus-239265 . August 25, 2016 . February 16, 2021. U.S. News & World Report.
  19. Web site: Geoffrey Beene David Agus. February 16, 2021. en-US.
  20. Web site: David Agus takes helm at USC Westside Cancer Center and Center for Applied Molecular Medicine. February 16, 2021. Nanowerk.
  21. Entrepreneurs' Organization. "Power Speakers" Retrieved May 6, 2009
  22. http://www.doctorsofusc.com/wcc "USC Westside Norris Cancer Center"
  23. Web site: October 25, 2009. New Cancer Research Center to be Based at USC. February 16, 2021. USC News. en-US. July 28, 2020. https://web.archive.org/web/20200728185737/https://news.usc.edu/27467/New-Cancer-Research-Center-to-be-Based-at-USC/. dead.
  24. Web site: David B. Agus. David B. Agus - World Economic Forum.
  25. Web site: TEDMED - Speaker: David Agus. TEDMED.
  26. Web site: December 1, 2010. Looking into the history and treatment of cancer. February 16, 2021. The Aspen Institute. en-US.
  27. Web site: David B. Agus, MD . Keck Medicine . February 22, 2014 . March 2, 2014 . https://web.archive.org/web/20140302001840/http://www.keckmedicine.org/doctor/david-b-agus/ . dead .
  28. Web site: Belvedere. Matthew J.. January 13, 2016. Top cancer doctor: Do these things to live longer. February 19, 2021. CNBC. en.
  29. Web site: david agus. NCBI.
  30. Web site: Membership Roster . Council on Foreign Relations . dead . https://web.archive.org/web/20140727040345/http://www.cfr.org/about/membership/roster.html . July 27, 2014 .
  31. Steve Jobs' Doctor Wants to Teach You the Formula for Long Life. en-us. Wired. February 19, 2021. 1059-1028.
  32. Web site: California Southern I Governor's Newsletter December 2016 California ACP. February 19, 2021. www.acponline.org.
  33. Web site: June 2, 2003. 'Dramatic' drug trial results offer hope for cancer patients. February 19, 2021. the Guardian. en.
  34. Web site: David Agus, M.D.. February 19, 2021. www.cbsnews.com. February 14, 2017 . en-US.
  35. Web site: Hsieh. Nathaniel. October 15, 2012. Prof focuses on cancer prevention. February 19, 2021. Daily Trojan. en-US.
  36. Web site: Ellison-Agus' Sensei separating farm, retreat units. February 19, 2021. mauinews.com. en-US.
  37. Web site: Project Ronin - Founded by David Agus, Larry Ellison, and Dave Hodgson . Project Ronin . March 14, 2022 . November 18, 2021 . https://web.archive.org/web/20211118062914/https://www.projectronin.com/mission . dead .
  38. News: . May 7, 2021 . Dr. David Agus announces new global initiative to track COVID variants using genomic sequencing . CBS News . November 21, 2022.
  39. News: . October 24, 2022 . The perilously small supply of psychiatrists. Politico . November 29, 2022.
  40. Web site: Expanding Our Global Impact Through the G20 and B20 . 2023-05-04 . www.institute.global . en-GB.
  41. News: BRAINSTORM HEALTH: CONNECTING THE WORLD . .
  42. Time 100 Health Summit . 2023-05-05 . Time . en.
  43. 2019-10-15 . 42nd U.S. President Bill Clinton to Join the TIME 100 Health Summit in New York, NY on October 17 . 2023-05-05 . Time . en.
  44. Web site: 2017-05-03 . The Urgency of Now: Dr. David Agus Interviews Former Vice President Joe Biden on the Cancer Moonshot Keck School of Medicine of USC . 2023-05-05 . en-US.
  45. Web site: Brainstorm Health 2022 - Leveraging New Frontiers: The Importance Of A Global Strategy . 2023-05-05 . fortune.com . en .
  46. Book: The End of Illness | Book by David B. Agus - Simon & Schuster . January 17, 2012 . Books.simonandschuster.com . 9781451610178 . September 16, 2012 . registration.
  47. Web site: Beyond the Dome . February 16, 2021 . www.hopkinsmedicine.org . en.
  48. Web site: July 31, 2018 . David B. Agus, MD Keck School of Medicine of USC . February 16, 2021 . en-US.
  49. News: Times . The New York . February 10, 2014 . Best Selling Science Books (Published 2014) . en-US . The New York Times . February 16, 2021 . 0362-4331.
  50. News: Stein . Joel . March 24, 2023 . Giving Up the Ghostwriter . LA Mag .
  51. Web site: Purtill . Corinne . 2023-03-06 . We found 95 instances of plagiarism in a USC scientist's new book. Sales have been suspended . 2023-05-05 . Los Angeles Times . en-US.
  52. Web site: March 17, 2023 . Examination of USC doctor's earlier books finds more troubling instances of plagiarism . Los Angeles Times.
  53. News: March 6, 2023 . Dr. David Agus accused of plagiarism, prompting book recall . . March 7, 2023.
  54. Web site: Goodwin . Grace Eliza . A famed oncologist's bestselling new health book about 'animal secrets' got yanked off the shelves after the LA Times discovered he copied from Wikipedia . 2023-05-05 . Insider . en-US.
  55. Book: The Book of Animal Secrets . 2023-06-11 . 978-1-6680-2257-3 . en . Agus . David B. . June 21, 2023 . Simon & Schuster .
  56. Web site: Congressional Record.
  57. Web site: January 25, 2012. Interview with the Author of "The End of Illness," David Agus, MD. February 18, 2021. ASCO Connection. en.
  58. Web site: David Agus, MD. February 18, 2021. USC Schaeffer. en-US.
  59. Agus. David B.. Cordon-Cardo. Carlos. Fox. William. Drobnjak. Marija. Koff. Andrew. Golde. David W.. Scher. Howard I.. November 3, 1999. Prostate Cancer Cell Cycle Regulators: Response to Androgen Withdrawal and Development of Androgen Independence. JNCI: Journal of the National Cancer Institute. en. 91. 21. 1869–1876. 10.1093/jnci/91.21.1869. 10547394. 0027-8874. free.
  60. Web site: January 25, 2012. Interview with the Author of "The End of Illness," David Agus, MD. February 19, 2021. ASCO Connection. en.
  61. Web site: David Agus, MD. February 19, 2021. USC Schaeffer. en-US.
  62. Web site: David Agus USC Profiles. February 19, 2021. profiles.sc-ctsi.org.
  63. Web site: Geoffrey Beene David Agus. February 19, 2021. en-US.
  64. Web site: Podcast with Dr. David Agus. February 19, 2021. BIO. en.
  65. Web site: Eleven Biotech Leaders Named to Biotech Humanitarian Award Judges Panel. February 19, 2021. BIO. en.
  66. News: Ted Johnson . November 29, 2022 . Paramount+ To Debut Dr. David Agus Docuseries Featuring Conversations With Ashton Kutcher, Nick Cannon And Other Celebrities About Their Health Struggles . Deadline . November 29, 2022.
  67. Agus . David B . Akita . Robert W . Fox . William D . Lewis . Gail D . Higgins . Brian . Pisacane . Paul I . Lofgren . Julie A . Tindell . Charles . Evans . Douglas P . Maiese . Krista . Scher . Howard I . Sliwkowski . Mark X . 2002-08-01 . Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth . Cancer Cell . en . 2 . 2 . 127–137 . 10.1016/S1535-6108(02)00097-1 . 12204533 . 1535-6108. free .
  68. Agus . David B. . Gordon . Michael S. . Taylor . Charles . Natale . Ronald B. . Karlan . Beth . Mendelson . David S. . Press . Michael F. . Allison . David E. . Sliwkowski . Mark X. . Lieberman . Gracie . Kelsey . Stephen M. . Fyfe . Gwen . 2005-04-10 . Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer . Journal of Clinical Oncology. 23 . 11 . 2534–2543 . 10.1200/JCO.2005.03.184 . 0732-183X . 15699478. free .
  69. Kang . Y.-K. . Rha . S. Y. . Tassone . P. . Barriuso . J. . Yu . R. . Szado . T. . Garg . A. . Bang . Y.-J. . August 2014 . A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer . British Journal of Cancer . en . 111 . 4 . 660–666 . 10.1038/bjc.2014.356 . 24960402 . 4134501 . 1532-1827.
  70. Research . Center for Drug Evaluation and . 2019-02-09 . FDA grants regular approval to pertuzumab for adjuvant treatment of HER2-positive breast cancer . FDA . en.
  71. Blumenthal . Gideon M. . Scher . Nancy S. . Cortazar . Patricia . Chattopadhyay . Somesh . Tang . Shenghui . Song . Pengfei . Liu . Qi . Ringgold . Kimberly . Pilaro . Anne M. . Tilley . Amy . King . Kathryn E. . Graham . Laurie . Rellahan . Barbara L. . Weinberg . Wendy C. . Chi . Bo . 2013-09-15 . First FDA approval of dual anti-HER2 regimen: pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer . Clinical Cancer Research. 19 . 18 . 4911–4916 . 10.1158/1078-0432.CCR-13-1212 . 1557-3265 . 23801166. 11348603 .
  72. News: . Weddings . Amy J. Povich . David B. Agus . June 5, 1994 . May 7, 2009 . August 31, 2009 . live . https://web.archive.org/web/20090831130358/http://query.nytimes.com/gst/fullpage.html?res=940DEFDA103BF936A35755C0A962958260%2F .
  73. Web site: Tiburon International Film Festival. February 9, 2021. www.tiburonfilmfestival.com.
  74. Web site: 2018-07-30 . David B. Agus, MD . 2023-05-05 . Los Angeles Business Journal . en-US.
  75. Web site: 2012-02-06 . Lance Armstrong & David Agus at TEDMED 2011 - YouTube . . 2023-05-05 . https://web.archive.org/web/20120206163600/https://www.youtube.com/watch?v=vq270S4pLQc . February 6, 2012 .
  76. News: Stein . Joel . February 2, 2022 . Can the World's Most Connected Doctor Cure Cancer? . LA Mag .
  77. News: Joe and Jill Biden launch new cancer initiative. February 9, 2021. Fierce Healthcare. June 27, 2017 . en.
  78. News: 2019-07-15 . Biden cancer group shuts down operations . en . Reuters . 2023-05-05.
  79. Web site: FinSMEs . 2022-05-03 . Imagene AI Raises $21.5M in Seed and Series A . 2023-05-02 . FinSMEs . en-US.
  80. Web site: Florko . Rebecca Robbins, Nicholas . 2020-04-29 . How a Los Angeles doctor got swept up in the swirl of the Trump White House as it confronts the pandemic . 2023-05-02 . STAT . en-US.
  81. Web site: Governance and Leadership. February 9, 2021. renewal.nli.org.il. October 19, 2021. https://web.archive.org/web/20211019195859/https://renewal.nli.org.il/Governance. dead.
  82. Web site: 2018. 2018 Impact Report. live. https://web.archive.org/web/20210214234101/https://www.peres-center.org/media/1711/peres-center-2018-impact-report.pdf . February 14, 2021 . peres-center.org.
  83. News: Loder . Kurt . Johnny Ramone Not Dying His Doctor Says . . June 16, 2004 . October 3, 2013 . October 5, 2013 . dead . https://web.archive.org/web/20131005110644/http://www.mtv.com/news/articles/1488468/johnny-ramone-not-dying-his-doctor.jhtml .

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