David A. Fidock Explained

David A. Fidock
Fields:Microbiology, immunology
Thesis Title:Molecular and Immuno-Epidemiological Studies of the Plasmodium falciparum STARP and LSA-1 Antigens Expressed During the Pre-Erythrocytic Stages in Humans
Thesis Year:1994
Doctoral Advisor:Pierre Druilhe

David A. Fidock (born 8 December 1965), is the CS Hamish Young Professor of Microbiology and Immunology and Professor of Medical Sciences at Columbia University Irving Medical Center in Manhattan.[1] [2] [3]

Education

Fidock attended the University of Adelaide and earned a bachelor of mathematical sciences and an honors degree in genetics in 1985. He earned a PhD in microbiology from the Institut Pasteur in Paris in 1994. His dissertation advisor was Pierre Druilhe, and his thesis was titled "Molecular and Immuno-Epidemiological Studies of the Plasmodium falciparum STARP and LSA-1 Antigens Expressed During the Pre-Erythrocytic Stages in Humans".[4] [5] [6] He underwent postdoctoral training with Anthony James at University of California, Irvine, and with Thomas Wellems at the National Institutes of Health.[4]

Career

After his post-doctoral training, Fidock joined the Albert Einstein College of Medicine in New York as an Assistant Professor in the Department of Microbiology and Immunology. In 2007, Fidock became an Associate Professor at Columbia University in the Departments of Microbiology and Immunology and of Medicine (Division of Infectious Diseases). Since 2008, Fidock has been a tenured Professor of Microbiology and Immunology and of Medical Sciences at Columbia. In 2017 he received the C.S. Hamish Young endowed Professorship. From 2008-2023 he served as the Program Director of the NIH T32-funded Graduate Program in Microbiology, Immunology, and Infection. In 2023, he was elected as the incoming President of the American Society of Tropical Medicine and Hygiene.[7]

Research

Fidock's research focuses on the genetic and molecular mechanisms behind antimalarial drug resistance in the human parasite Plasmodium falciparum, as well as target-based drug discovery and development, and parasite metabolism and biology.[8] [9] [10] He led the development of methods for genetically modifying malaria parasites and for elucidating the genetic basis of P. falciparum resistance to various first-line medicines (including artemisinin, chloroquine and piperaquine).[11] [12] [13]

He has published more than 280 papers on malaria, with a current h-index of 97. His work has been cited over 34,000 times. His work has been funded by the NIH, the Bill & Melinda Gates Foundation, the Department of Defense, the Burroughs Wellcome Fund and the Medicines for Malaria Venture.[14]

Honors

Publications

External links

Notes and References

  1. Web site: Faculty - David A. Fidock . 2022-01-04 . Department of Microbiology & Immunology -US.
  2. Web site: 2017-06-12 . David A. Fidock, PhD . 2022-01-04 . Vagelos College of Physicians and Surgeons .
  3. Web site: David Fidock . 2022-01-04 . scholar.google.com.
  4. Web site: 12 June 2017 . David A. Fidock, PhD . 2022-01-04 . Columbia University.
  5. Web site: David Fidock . https://web.archive.org/web/20220721194341/http://delgeme.org/en/who-are-we/stab-membership/david-fidock . 2022-07-21 . 2022-01-04 . Delgeme.
  6. Web site: 2021 . Welcome Message from our President, Dr. Mahalia Desruisseaux . ASTMH.
  7. Web site: David Fidock . 2023-12-01 . The Fidock Lab . en-US.
  8. Web site: 18 December 2020 . MMV awards Project of the Year 2020 to Professor David Fidock and team for critical contribution to malaria drug resistance profiling Medicines for Malaria Venture . 2022-01-04 . www.mmv.org.
  9. Blasco . Benjamin . Leroy . Didier . Fidock . David A . 2017-08-04 . Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic . Nature Medicine . 23 . 8 . 917–928 . 10.1038/nm.4381 . 1078-8956 . 5747363 . 28777791.
  10. Miguel-Blanco . Celia . Murithi . James M. . Benavente . Ernest Diez . Angrisano . Fiona . Sala . Katarzyna A. . van Schalkwyk . Donelly A. . Vanaerschot . Manu . Schwach . Frank . Fuchter . Matthew J. . Billker . Oliver . Sutherland . Colin J. . 2021-01-21 . The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957 . Scientific Reports . 11 . 1 . 1888 . 10.1038/s41598-021-81343-z . 2045-2322 . 7820608 . 33479319.
  11. Duffey . Maëlle . Blasco . Benjamin . Burrows . Jeremy N. . Wells . Timothy N. C. . Fidock . David A. . Leroy . Didier . 2021-08-01 . Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials . Trends in Parasitology . 37 . 8 . 709–721 . 10.1016/j.pt.2021.04.006 . 1471-4922 . 8282644 . 34001441.
  12. Ekland . Eric H. . Fidock . David A. . August 2007 . Advances in understanding the genetic basis of antimalarial drug resistance . Current Opinion in Microbiology . 10 . 4 . 363–370 . 10.1016/j.mib.2007.07.007 . 1369-5274 . 2080794 . 17709280.
  13. Miguel-Blanco . Celia . Murithi . James M. . Benavente . Ernest Diez . Angrisano . Fiona . Sala . Katarzyna A. . van Schalkwyk . Donelly A. . Vanaerschot . Manu . Schwach . Frank . Fuchter . Matthew J. . Billker . Oliver . Sutherland . Colin J. . 2021-01-21 . The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957 . Scientific Reports . 11 . 1 . 1888 . 10.1038/s41598-021-81343-z . 2045-2322 . 7820608 . 33479319.
  14. Web site: David Fidock . 2023-12-01 . Advance The Global Australian Network . en-AU.
  15. Web site: astmh.org.
  16. Web site: 18 December 2020 . MMV awards Project of the Year 2020 to Professor David Fidock and team for critical contribution to malaria drug resistance profiling - Medicines for Malaria Venture . 2022-03-16 . www.mmv.org.
  17. Mok . Sachel . Fidock . David A. . 2023-10-16 . Determinants of piperaquine-resistant malaria in South America . The Lancet. Infectious Diseases . S1473–3099(23)00564–9 . 10.1016/S1473-3099(23)00564-9 . 1474-4457 . 37858324. free . 10872569 .
  18. Murithi. James M.. Deni. Ioanna. Pasaje. Charisse Flerida A.. Okombo. John. Bridgford. Jessica L.. Gnädig. Nina F.. Edwards. Rachel L.. Yeo. Tomas. Mok. Sachel. Burkhard. Anna Y.. Coburn-Flynn. Olivia. 2021-07-06. The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biologyglish. 29 . 5 . S2451-9456(21)00305–6. 10.1016/j.chembiol.2021.06.006. 2451-9456. 34233174. 8727639.
  19. Stokes. Barbara H. Dhingra. Satish K. Rubiano. Kelly. Mok. Sachel. Straimer. Judith. Gnädig. Nina F. Deni. Ioanna. Schindler. Kyra A. Bath. Jade R. Ward. Kurt E. Striepen. Josefine. 2021-07-19. Soldati-Favre. Dominique. Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. eLife. 10. e66277. 10.7554/eLife.66277. 2050-084X. 8321553. 34279219 . free .
  20. Vanaerschot. Manu. Murithi. James M.. Pasaje. Charisse Flerida A.. Ghidelli-Disse. Sonja. Dwomoh. Louis. Bird. Megan. Spottiswoode. Natasha. Mittal. Nimisha. Arendse. Lauren B.. Owen. Edward S.. Wicht. Kathryn J.. 2020-07-16. Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. Cell Chemical Biologyglish. 27. 7. 806–816.e8. 10.1016/j.chembiol.2020.04.001. 2451-9456. 7369637. 32359426.
  21. Gnädig. Nina F.. Stokes. Barbara H.. Edwards. Rachel L.. Kalantarov. Gavreel F.. Heimsch. Kim C.. Kuderjavy. Michal. Crane. Audrey. Lee. Marcus C. S.. Straimer. Judith. Becker. Katja. Trakht. Ilya N.. 2020-04-20. Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13. PLOS Pathogens. 16. 4. e1008482. 10.1371/journal.ppat.1008482. 1553-7374. 7192513. 32310999 . free .
  22. Stokes . Barbara H. . Yoo . Euna . Murithi . James M. . Luth . Madeline R. . Afanasyev . Pavel . Fonseca . Paula C. A. da . Winzeler . Elizabeth A. . Elizabeth A. Winzeler . Ng . Caroline L. . Bogyo . Matthew . Fidock . David A. . 2019-06-06 . Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents . PLOS Pathogens . 15 . 6 . e1007722 . 10.1371/journal.ppat.1007722 . 1553-7374 . 6553790 . 31170268 . free.
  23. Dhingra. Satish K.. Small-Saunders. Jennifer L.. Ménard. Didier. Fidock. David A.. 2019-11-01. Plasmodium falciparum resistance to piperaquine driven by PfCRT. The Lancet Infectious Diseasesglish. 19. 11. 1168–1169. 10.1016/S1473-3099(19)30543-2. 1473-3099. 6943240. 31657776.
  24. Kim. Jonathan. Tan. Yong Zi. Wicht. Kathryn J.. Erramilli. Satchal K.. Dhingra. Satish K.. Okombo. John. Vendome. Jeremie. Hagenah. Laura M.. Giacometti. Sabrina I.. Warren. Audrey L.. Nosol. Kamil. December 2019. Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature. 576. 7786. 315–320. 10.1038/s41586-019-1795-x. 1476-4687. 6911266. 31776516.

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