David A. Eisner Explained

David Eisner
Birth Name:David Alfred Eisner
Birth Date:1955 1, df=y
Birth Place:Manchester
Workplaces:University College London, University of Liverpool, University of Manchester
Thesis Title:The effects of sodium pump inhibition on the electrical and mechanical properties of mammalian cardiac muscle.
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Thesis Year:1979
Doctoral Advisor:Denis Noble
Awards:Physiological Society Annual Review Prize Lecture (2017)
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David Alfred Eisner, FRCP (Hon), FMedSci,[1] (born 3 January 1955)[2] [3] is British Heart Foundation Professor of Cardiac Physiology at the University of Manchester and editor-in-chief of The Journal of General Physiology (JGP).[4]

Education

Eisner was born in 1955 in Manchester, the son of the physicist and writer Herbert Eisner.[5] [6] After attending Manchester Grammar School, he received his B.A. in natural sciences at King's College, Cambridge in 1976. In 1979 he obtained a D.Phil. in physiology at Oxford University in the laboratory of Denis Noble for work on the sodium pump in cardiac muscle.

Career

Following postdoctoral research at the University of Cambridge on the kinetics of the sodium pump[7] in the laboratory of Ian Glynn, he took up a lectureship in the Department of Physiology at University College London in 1980. In 1990 he moved to The University of Liverpool as professor of veterinary biology. In 1999 he took up a chair of cardiac physiology at the University of Manchester and, in 2000, was awarded the BHF Chair of Cardiac Physiology.[8]

Eisner was chair of the editorial board of The Journal of Physiology from 1997 to 2000[9] and editor-in chief of the Journal of Molecular and Cellular Cardiology from 2007 to 2016. He was president of The Federation of European Physiological Societies (FEPS) from 2011-2015[10] and The Physiological Society from 2016 to 2018.

Research

Eisner's early research focused on the regulation of intracellular sodium in cardiac muscle and the effects on contraction.[11] He then investigated the control of intracellular calcium concentration[12] and its role in the production of arrhythmias.[13] He has identified the factors that regulate the calcium content of the sarcoplasmic reticulum[14] [15] and how this is altered in disease.[16] His recent research has focused on the control of diastolic calcium[17] [18] and the effects of calcium buffering.[19] [20] He has also written[21] and spoken[22] about scientific reproducibility and fraud.

Personal life

Eisner is married to Susan Wray, professor of cellular and molecular physiology at the University of Liverpool, with whom he has three children.

Honours and awards

Eisner was elected as a Fellow of The Academy of Medical Sciences in 1999[23] and The International Society for Heart Research in 2001.[24] and as a Member of Academia Europaea in 2007.[25] He was elected to Honorary Fellowship of The Royal College of Physicians in 2010. In 2018 he received an honorary doctorate, Doctor Honoris Causa, from The University of Debrecen.[26] and, in 2021 from The University of Szeged.[27] Prizes awarded to him include: The GL Brown[28] [29] and Annual Review Lecture[30] of The Physiological Society; the Keith Reimer Lecture[31] [32] and the Peter Harris Distinguished Scientist Award of the International Society for Heart Research; the Carmeliet-Coraboeuf-Weidmann Lecture of the European Working Group on Cardiac Cellular Electrophysiology;[33] the Fabio Ruzzier Lecture of The Italian Physiological Society.[34] He has also delivered the Burdon-Sanderson Lecture (Oxford) in 2013.[35]

Notes and References

  1. Web site: Professor of Cardiac Physiology: Prof David Eisner M.A. D.Phil, FRCP (Hon), FMedSci . University of Manchester . 30 April 2017.
  2. Web site: CURRICULUM VITAE – David Alfred Eisner. ae-info.org. Academia Europaea. 30 April 2017. November 2009.
  3. ‘EISNER, Prof. David Alfred’, Who's Who 2017, A & C Black, an imprint of Bloomsbury Publishing plc, 2017; online edn, Oxford University Press, 2016 ; online edn, Nov 2016
  4. Web site: Editors and Staff. rupress.org. 2 January 2020.
  5. News: Herbert Eisner. The Daily Telegraph. 28 July 2011. 17 November 2018. 0307-1235.
  6. 20 July 2010. European Perspectives. Circulation. 122. 3. 10.1161/cir.0b013e3181e8eb7f. 0009-7322. free.
  7. Eisner DA, Richards DE . The interaction of potassium ions and ATP on the sodium pump of resealed red cell ghosts . The Journal of Physiology . 319 . 403–18 . 1981 . 7320919 . 1243847 . 10.1113/jphysiol.1981.sp013917 .
  8. Web site: BHF Professor David Eisner – heart attack and arrhythmias . British Heart Foundation . 30 April 2017.
  9. Web site: Past Officers of the Physiological Society (1876–2001) . physoc.org . 30 April 2017.
  10. Web site: Past Officers of FEPS . 2022-11-10 . www.feps.org.
  11. Eisner DA, Lederer WJ, Vaughan-Jones RD . The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres . The Journal of Physiology . 317 . 163–87 . August 1981 . 7310731 . 1246783 . 10.1113/jphysiol.1981.sp013819 .
  12. Allen DG, Eisner DA, Orchard CH . Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle . The Journal of Physiology . 350 . 615–30 . May 1984 . 6747860 . 1199289 . 10.1113/jphysiol.1984.sp015221 .
  13. Orchard CH, Eisner DA, Allen DG . Oscillations of intracellular Ca2+ in mammalian cardiac muscle . Nature . 304 . 5928 . 735–8 . 1983 . 6888540 . 10.1038/304735a0 . 1983Natur.304..735O . 4306804 .
  14. Eisner DA, Trafford AW, Díaz ME, Overend CL, O'Neill SC . The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation . Cardiovascular Research . 38 . 3 . 589–604 . June 1998 . 9747428 . 10.1016/s0008-6363(98)00062-5 . free .
  15. Trafford AW, Díaz ME, Eisner DA . Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current . Circulation Research . 88 . 2 . 195–201 . February 2001 . 11157672 . 10.1161/01.res.88.2.195 . free .
  16. Kashimura T, Briston SJ, Trafford AW, Napolitano C, Priori SG, Eisner DA, Venetucci LA . In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves . Circulation Research . 107 . 12 . 1483–9 . December 2010 . 20966392 . 10.1161/CIRCRESAHA.110.227744 . free .
  17. Eisner. David A.. Caldwell. Jessica L.. Trafford. Andrew W.. Hutchings. David C.. 31 January 2020. The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications. Circulation Research. 126. 3. 395–412. 10.1161/CIRCRESAHA.119.315891. 31999537. 7004450. 0009-7330. free.
  18. Sankaranarayanan R, Kistamás K, Greensmith DJ, Venetucci LA, Eisner DA . i regulates diastolic levels in rat ventricular myocytes . The Journal of Physiology . 595 . 16 . 5545–5555 . August 2017 . 28617952 . 5556151 . 10.1113/JP274366 .
  19. Smith GL, Eisner DA . Calcium Buffering in the Heart in Health and Disease . Circulation . 139 . 20 . 2358–2371 . May 2019 . 31082292 . 6520234 . 10.1161/CIRCULATIONAHA.118.039329 .
  20. Eisner . David . Neher . Erwin . Taschenberger . Holger . Smith . Godfrey . 2023-06-16 . Physiology of intracellular calcium buffering . Physiological Reviews . 103 . 4 . 2767–2845 . 10.1152/physrev.00042.2022 . 1522-1210 . 37326298. free .
  21. Eisner. D. A.. January 2018. Reproducibility of science: Fraud, impact factors and carelessness. Journal of Molecular and Cellular Cardiology. 114. 364–368. 10.1016/j.yjmcc.2017.10.009. 1095-8584. 6565841. 29079076.
  22. Web site: Does the 'system' reward fraud?. 17 April 2020. Youtube. live. https://web.archive.org/web/20210625074011/https://www.youtube.com/watch?v=vAlDrx5IJ2c . 25 June 2021 .
  23. Web site: Professor David Eisner | The Academy of Medical Sciences . Acmedsci.ac.uk . 30 April 2017.
  24. Web site: Fellows of the ISHR . International Society for Heart Research . 30 April 2017.
  25. Web site: Academy of Europe: Eisner David . Ae-info.org . 30 April 2017.
  26. Web site: University of Debrecen -. születnek. www.WebDeb.hu – ahol a weblapok. edu.unideb.hu. 15 June 2018.
  27. Web site: Szeged University, University Day 2021. 13 November 2021 . live. https://web.archive.org/web/20211116134448/https://u-szeged.hu/sztehirek/2021-november/diszdoktori-cimek?objectParentFolderId=19396 . 16 November 2021 .
  28. Web site: GL Brown Prize Lecture | Physiological Society . Physoc.org . 29 May 2011 . 30 April 2017.
  29. Web site: Calcium in the heart: from physiology to disease – David Eisner (GL Brown Lecture 2014) . YouTube . 16 May 2014 . 30 April 2017.
  30. Eisner DA . Ups and downs of calcium in the heart . The Journal of Physiology . 596 . 1 . 19–30 . January 2018 . 29071725 . 5746526 . 10.1113/JP275130 .
  31. Web site: ISHR Hall of Fame . International Society for Heart Research . 30 April 2017.
  32. Eisner DA, Kashimura T, O'Neill SC, Venetucci LA, Trafford AW . What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? . Journal of Molecular and Cellular Cardiology . 46 . 4 . 474–81 . April 2009 . 19150449 . 10.1016/j.yjmcc.2008.12.005 .
  33. escardio. 25 October 2013. The Carmeliet-Coraboeuf-Weidmann Lecture – David Eisner.
  34. Web site: Lectures. FEPS SIF 2019. 25 June 2019.
  35. Web site: Sir John Burdon-Sanderson Prize Lecture Series – Physiology, Anatomy and Genetics. University of Oxford. 26 February 2020. 18 February 2020. https://web.archive.org/web/20200218073859/https://www.dpag.ox.ac.uk/about-us/john-burdon-sanderson-lecture. dead.

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