Daturaolone Explained

Daturaolone is a pentacyclic oleanane triterpenoid,[1] also known as 3-oxo-6-β-hydroxy-β-amyrin,[2] found in Datura species such as Datura stramonium[3] and Datura innoxia.[4]

History

It was isolated for the first time from Solanum arundo.[5]

Structure

Daturaolone contains five rings with a ketone group and a hydroxyl group, which may be essential for its bioactivities. The structure was deduced through mass spectroscopy and 1H NMR spectroscopy.[6]

Functions

Daturaolone isolated from Datura metel Linnaeus has been found to have anti-fungal and anti-bacterial activities. When tested against bacterial strains such as Klebsiella pneumoniae and S. aureus, daturaolone was shown to inhibit bacterial growth.[7]

See also

Notes and References

  1. Baig . Muhammad Waleed . Fatima . Humaira . Akhtar . Nosheen . Hussain . Hidayat . Okla . Mohammad K. . Al-Hashimi . Abdulrahman . Al-Qahtani . Wahidah H. . AbdElgawad . Hamada . Haq . Ihsan-ul . 2021-11-30 . Anti-Inflammatory Potential of Daturaolone from Datura innoxia Mill.: In Silico, In Vitro and In Vivo Studies . Pharmaceuticals . 14 . 12 . 1248 . 10.3390/ph14121248 . 1424-8247 . 8708807 . 34959649. free .
  2. Bawazeer . Saud . Rauf . Abdur . Bawazeer . Sami . 2020 . Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel's Trumpet) Fruits . Frontiers in Pharmacology . 11 . 544794 . 10.3389/fphar.2020.544794 . 1663-9812 . 7546419 . 33101017. free .
  3. Li J, Lin B, Wang G, Gao H, Qin M . [Chemical constituents of Datura stramonium seeds] . zh . Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica . 37 . 3 . 319–22 . February 2012 . 22568232 .
  4. Kocór M, Pyrek JS, Atal CK, Bedi KL, Sharma BR . Triterpenes of Datura innoxia Mill. Structure of daturadiol and daturaolone . . 38 . 21 . 3685–8 . October 1973 . 4745874 . 10.1021/jo00961a005 .
  5. Grace MH, Saleh MM . Hepato-protective effect of daturaolone isolated from Solanum arundo . . 51 . 8 . 593–5 . August 1996 . 8794471 .
  6. Grace . M. H. . Saleh . M. M. . August 1996 . Hepato-protective effect of daturaolone isolated from Solanum arundo . Die Pharmazie . 51 . 8 . 593–595 . 0031-7144 . 8794471.
  7. Bawazeer . Sami . Rauf . Abdur . 2021-09-18 . In Vitro Antibacterial and Antifungal Potential of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus . BioMed Research International . 2021 . 1543574 . 10.1155/2021/1543574 . 2314-6133 . 8476240 . 34589544. free .

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