Darinaparsin Explained

Tradename:Darvias; Zinapar
Synonyms:SP-02; ZIO-101; DMAs(III)G
Atc Prefix:None
Legal Status:Rx in Japan
Cas Number:69819-86-9
Pubchem:11683005
Drugbank:DB06179
Chembl:3247378
Chebi:94295
Chemspiderid:9857733
Unii:9XX54M675G
Kegg:D08898
Iupac Name:(2S)-2-Amino-5-(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-ylamino]-5-oxopentanoic acid
Smiles:C[As](C)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
Stdinchi:1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
Stdinchikey:JGDXFQORBMPJGR-YUMQZZPRSA-N
C:12
H:22
As:1
N:3
O:6
S:1

Darinaparsin (trade names Darvias and Zinapar) is a drug for the treatment of various types of cancer.[1] It is an arsenic-containing derivative of glutathione.[2]

The mechanism of action of darinaparsin is proposed to involve disruption of mitochondrial function, increased production of reactive oxygen species, and modulation of intracellular signal transduction pathways, thereby inducing cell cycle arrest and apoptosis in cancer cells.[3]

History

Darinaparsin and related compounds were first studied in the 1970s at Texas A&M University. It wasn't until 1998, when a connection between organoarsenic compounds and their potential use in cancer chemotherapy was reported, that interest in darinaparsin as a pharmaceutical drug began.[4] Darinaparsin was licensed to Ziopharm Oncology and then Solasia Pharma for drug development.[4] In 2018, Solasia Pharma licensed Darinaparsin to HB Human BioScience SAS of Bogota Colombia.[5] HB Human BioScience SAS began the registration process in Colombia, Peru, Ecuador, Venezuela, Chile, Panama, Costa Rica, and Guatemala, while offering Darinaparsin on a compassionate use (expanded access) basis.

Darinaparsin was granted Orphan Drug Designation in the US and Europe as a treatment for peripheral T-cell lymphoma (PTCL).[6]

In Japan, darinaparsin was approved for relapsed or refractory PTCL in June 2022.[7]

Darinaparsin was submitted for INVIMA Approval in Colombia on December 12, 2023[8]

Notes and References

  1. Web site: Darinaparsin - Solasia Pharma . Adis Insight . Springer Nature Switzerland AG .
  2. Web site: Darinaparsin . NCI Drug Dictionary . National Cancer Institute .
  3. Web site: SP-02 . Solasia .
  4. Quintás-Cardama A, Verstovsek S, Freireich E, Kantarjian H, Chen YW, Zingaro R . Chemical and clinical development of darinaparsin, a novel organic arsenic derivative . Anti-Cancer Agents in Medicinal Chemistry . 8 . 8 . 904–909 . December 2008 . 19075572 . 10.2174/187152008786847666 .
  5. Web site: August 17, 2018 . Announcement Concerning Signing of License and Distribution Agreement for SP-02 (darinaparsin injection) in Latin America . November 10, 2023 . Solasia.
  6. Web site: Darinaparsin . Inxight Drugs . National Institutes of Health .
  7. Solasia Pharma: DARVIAS® Injection 135mg (Generic Name: DARINAPARSIN /Development Code: SP-02) Approved in Japan . June 19, 2022 .
  8. https://enlinea.invima.gov.co/TransparenciaWeb/faces/index.xhtml;jsessionid=b1_uPWvdRSS3E5fi8FrelO4vqpxAKSar3kv1HLJO.srvvwfly02