Darier's sign explained

Darier's sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa.^[1]

In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the lesional skin.

Eponym

Darier's sign is named after the French dermatologist Ferdinand-Jean Darier (1856–1938) who first described it.^{[2] [3]}

See also

• Dermatographic urticaria

Notes and References

1. Freiman . Anatoli . Kalia . Sunil . O'Brien . Elizabeth A. . Dermatologic Signs . Journal of Cutaneous Medicine and Surgery . July 2006 . 10 . 4 . 175–182 . 10.2310/7750.2006.00042.
2. Book: Crissey . John Thorne . Parish . Lawrence C. . Holubar . Karl . Historical Atlas of Dermatology and Dermatologists . 2013 . CRC Press . 978-1-84184-864-8 . 75. https://books.google.com/books?id=7ThZDwAAQBAJ&pg=PA75. Late nineteenth century French dermatology. en.
3. Book: Mosby's Pocket Dictionary of Medicine, Nursing & Health Professions . 2024 . Elsevier . St. Louis, Missouri . 978-0-323-83291-5 . 343 . Ninth . en.