| Daphne Karagianis | |
| Fullname: | Daphne Karagianis |
| Birth Date: | 31 August 1985 |
| Currentteam: | DNA Pro Cycling |
| Discipline: | Road |
| Role: | Rider |
| Amateuryears1: | 2011–2016 |
| Amateurteam1: | Chicago Cuttin' Crew |
| Amateuryears2: | 2017 |
| Amateurteam2: | Velo Classic p/b Stan's NoTubes |
| Amateuryears3: | 2018 |
| Amateurteam3: | The Meteor // Intelligentsia |
| Amateuryears4: | 2020 |
| Amateurteam4: | LA Sweat |
| Proyears1: | 2019, 2022 |
| Proteam1: | [1] DNA Pro Cycling |
Daphne Karagianis (born August 31, 1985) is an American racing cyclist, who currently rides for American UCI Continental team DNA Pro Cycling.