Dapagliflozin/saxagliptin explained
| Type: | combo |
| Component1: | Dapagliflozin |
| Class1: | SGLT-2 inhibitor |
| Component2: | Saxagliptin |
| Class2: | Dipeptidyl peptidase-4 inhibitor |
| Tradename: | Qtern |
| Dailymedid: | Qtern |
| Pregnancy Au: | D |
| Pregnancy Au Comment: | [1] |
| Routes Of Administration: | By mouth |
| Atc Prefix: | A10 |
| Atc Suffix: | BD21 |
| Legal Us: | Rx-only |
| Legal Eu: | Rx-only |
| Cas Number: | 2446322-16-1 |
| Kegg: | D10826 |
Dapagliflozin/saxagliptin, sold under the brand name Qtern, is a fixed-dose combination anti-diabetic medication used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.[2] [3] It is a combination of dapagliflozin and saxagliptin. It is taken by mouth.
The most common side effects include upper respiratory tract infection (such as nose and throat infections) and, when used with a sulphonylurea, hypoglycaemia (low blood glucose levels).
Dapagliflozin/saxagliptin was approved for medical use in the European Union in July 2016, and in the United States in February 2017.[4]
Medical uses
In the United States, dapagliflozin/saxagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
In the European Union, it is indicated in adults aged 18 years and older with type 2 diabetes:
- to improve glycemic control when metformin with or without sulphonylurea (SU) and either saxagliptin or dapagliflozin does not provide adequate glycemic control.
- when already being treated with saxagliptin and dapagliflozin.
Notes and References
- Web site: Dapagliflozin / saxagliptin (Qtern) Use During Pregnancy . Drugs.com . 28 June 2019 . 14 July 2020 . 16 July 2020 . https://web.archive.org/web/20200716125139/https://www.drugs.com/pregnancy/dapagliflozin-saxagliptin.html . live .
- Web site: Qtern- dapagliflozin and saxagliptin tablet, film coated . DailyMed . 24 January 2020 . 14 July 2020 . 14 July 2020 . https://web.archive.org/web/20200714202647/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=423c489c-085b-4320-b892-7868ebd6dc6b . live .
- Web site: Qtern EPAR . European Medicines Agency (EMA) . 17 September 2018 . 14 July 2020 . 14 July 2020 . https://web.archive.org/web/20200714202658/https://www.ema.europa.eu/en/medicines/human/EPAR/qtern . live . Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- Web site: Drug Approval Package: Qtern (dapagliflozin and saxagliptin) . U.S. Food and Drug Administration (FDA) . 10 October 2018 . 14 July 2020 . 14 July 2020 . https://web.archive.org/web/20200714202646/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/209091Orig1s000TOC.cfm . live .
