Danuglipron Explained
| Legal Status: | Investigational |
| Synonyms: | PF-06882961 |
| Cas Number: | 2230198-02-2 |
| Chembl: | 4518483 |
| Pubchem: | 134611040 |
| Unii: | DN9IUI24GP |
| Iupac Name: | 2-4-[6-[(4-Cyano-2-fluorophenyl)methoxy]pyridin-2-yl]piperidin-1-ylmethyl]-3-(2S)-oxetan-2-ylmethyl]benzimidazole-5-carboxylic acid |
| C: | 31 |
| H: | 30 |
| F: | 1 |
| N: | 5 |
| O: | 4 |
| Stdinchi: | 1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1 |
| Stdinchikey: | HYBAKUMPISVZQP-DEOSSOPVSA-N |
| Smiles: | C1CO[C@@H]1CN2C3=C(C=CC(=C3)C(=O)O)N=C2CN4CCC(CC4)C5=NC(=CC=C5)OCC6=C(C=C(C=C6)C#N)F |
Danuglipron is a small-molecule GLP-1 agonist developed by Pfizer[1] that, in an oral formulation, is under investigation as a therapy for diabetes mellitus. Initial results from a randomized controlled trial indicate that it reduced weight[2] and improved diabetic control. The most commonly reported adverse events were nausea, diarrhea, and vomiting.[3] [4]
See also
Notes and References
- Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA . 6 . A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor . Journal of Medicinal Chemistry . 65 . 12 . 8208–8226 . June 2022 . 35647711 . 9234956 . 10.1021/acs.jmedchem.1c01856 .
- https://angeliclifttrio.com/ozempic-weight-loss-prescription-near-me-in-miami-fl-wegovy-semaglutide-injections/ Medical Weight Loss
- Saxena AR, Frias JP, Brown LS, Gorman DN, Vasas S, Tsamandouras N, Birnbaum MJ . Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial . JAMA Network Open . 6 . 5 . e2314493 . May 2023 . 37213102 . 10203889 . 10.1001/jamanetworkopen.2023.14493 .
- Web site: Constantino . Annika Kim . 2023-12-02 . Pfizer's twice-daily weight loss pill joins a long list of obesity drug flops . 2023-12-03 . CNBC . en.
