Daniel Herschlag Explained

Daniel Herschlag
Birth Date:	16 October 1958
Nationality:	American
Fields:	Biochemistry
Workplaces:	Stanford University
Alma Mater:	Binghamton University, Brandeis University, University of Colorado at Boulder
Doctoral Advisor:	William Jencks
Academic Advisors:	Tom Cech
Doctoral Students:	Rhiju Das Geeta Narlikar
Known For:	Enzymology RNA biochemistry
Awards:	William C. Rose Award (2010)

Daniel Herschlag (born October 16, 1958) is an American biochemist and Professor of Biochemistry at the Stanford University School of Medicine. His research uses an interdisciplinary approach to advance our understanding of the fundamental behavior of RNA and proteins. He is well known for his application of rigorous kinetic and mechanistic approaches to RNA and protein systems.^[1]

Education

Herschlag received a B.S. degree in biochemistry from Binghamton University in 1982. He began his graduate studies at University of Minnesota then moved on to complete his Ph.D. degree in Biochemistry at Brandeis University under W.P. Jencks in 1988.^[2]

Career

Herschlag was a Helen Hay Whitney Postdoctoral Fellow at the University of Colorado at Boulder from 1989 to 1992.^[3] He conducted post-doctoral research on the mechanism of the newly discovered RNA self-splicing reaction in the lab of Tom Cech.

In 1992, Herschlag joined the faculty of the Department of Biochemistry in the Stanford University School of Medicine, earning tenure in 1997. He was promoted to full professor in 2002.

In 2011, he was appointed the Senior Associate Dean of Graduate Education and Postdoctoral Affairs for the Stanford University School of Medicine.^{[4] [5]}

Selected awards

• Pfizer Award in Enzyme Chemistry, 1997^[6]
• Cope Scholar Award from the American Chemical Society, 2000^[7]
• ASBMB William Rose Award, 2010^[8]
• National Academy of Sciences Inductee, 2018^{[9] [10]}
• Biophysical Society Founders Award, 2020^{[11] [12]}

Selected publications

• 10.1038/344405a0 . DNA cleavage catalysed by the ribozyme from Tetrahymena . 1990 . Herschlag . Daniel . Cech . Thomas R. . Nature . 344 . 6265 . 405–9 . 1690858. 1990Natur.344..405H . 4242188 .
• 7545662 . 1995 . Herschlag . Daniel . RNA Chaperones and the RNA Folding Problem . 270 . 36 . 20871–4 . The Journal of Biological Chemistry . 10.1074/jbc.270.36.20871 . free .
• 10.1016/S1074-5521(99)80033-7 . Catalytic promiscuity and the evolution of new enzymatic activities . 1999 . O'Brien . Patrick J . Herschlag . Daniel . Chemistry & Biology . 6 . 4 . 10099128 . R91–R105. free .
• 10.1073/pnas.221593598 . Exploring the Folding Landscape of a Structured RNA . 2001 . Proceedings of the National Academy of Sciences . 99 . Rick . Russell . Xiaowei . Zhuang . Hazen P. . Babcock . Ian S. . Millett . Sebastian . Doniach . Steven . Chu . Daniel . Herschlag . 3057508 . 2002PNAS...99..155R . 11756689 . 155–60 . 1 . 117531. free .
• 10.1021/ja056528r . Alkaline Phosphatase Mono- and Diesterase Reactions: Comparative Transition State Analysis . 2006 . Zalatan . Jesse G. . Herschlag . Daniel . Journal of the American Chemical Society . 128 . 4 . 1293–303 . 16433548 . 2538955.
• 10.1038/nature08717 . Multiple native states reveal persistent ruggedness of an RNA folding landscape . 2010 . Solomatin . Sergey V. . Greenfeld . Max . Chu . Steven . Herschlag . Daniel . Nature . 463 . 7281 . 681–4 . 20130651 . 2818749. 2010Natur.463..681S .
• 10.1073/pnas.2220485120 . Dissecting the energetic architecture within an RNA tertiary structural motif via high-throughput thermodynamic measurements. . 2023 . Shin . John H. . Bonilla . Steve L. . Denny . Sarah K. . Greenleaf . William J. . Herschlag . Daniel . Proc Natl Acad Sci U S A . 120 . 11 . e2220485120 . 36897989 . 10243134 . 2023PNAS..12020485S .

Personal

Herschlag currently lives in Menlo Park, CA with his wife and two children.

See also

• List of RNA biologists

External links

• Herschlag Lab Website
• Stanford University School of Medicine Biochemistry Department
• Stanford Community Academic Profile, Daniel Herschlag

Notes and References

1. News: Daniel Herschlag named this year's William C. Rose Award winner. 7 April 2013. ASBMB. 9 November 2012. https://web.archive.org/web/20121109162504/http://www.asbmb.org/Meetings_01/2010mtg/2010mtgint.aspx?id=3898. dead.
2. News: Meet Dr. Herschlag from Stanford University. 7 April 2013. UCSF. 6 September 2012.
3. Web site: Helen Hay Whitney Foundation award list. dead. https://web.archive.org/web/20160304043300/http://www.hhwf.org/Dir/detail.php?id=301. 2016-03-04.
4. Web site: Stanford Dean's Newsletter. 2012-10-14. 2013-01-25. https://web.archive.org/web/20130125214556/http://deansnewsletter.stanford.edu/archive/07_25_11.html#12. dead.
5. Web site: Stanford University School of Medicine Leadership List. 2012-10-14. https://web.archive.org/web/20121014131419/http://med.stanford.edu/leadership/senior_deans.html. 2012-10-14. dead.
6. Web site: Pfizer Awardees List. 2012-10-14. 2017-01-01. https://web.archive.org/web/20170101193005/http://www.divbiolchem.org/content/pfizerawardees1.pdf. dead.
7. Web site: Cope Scholar Award Announcement.
8. Web site: ASBMB William Rose award announcement.
9. Web site: Dan Herschlag. www.nasonline.org. 2020-01-31.
10. Web site: Three Stanford faculty elected to the National Academy of Sciences. University. Stanford. 2018-05-02. Stanford News. en. 2020-01-31.
11. Web site: Dan Herschlag to Receive Biophysical Society's 2020 Founders Award. The Biophysical Society. en-US. 2020-01-31.
12. Web site: RNA chaperoning earns alumnus science accolades – Alumni Association Binghamton University. Alumni Association - Binghamton University. en. 2020-02-15.