| Honorific-Prefix: | The Hon. |
| Daniel Derbyshire | |
| Smallimage: | Daniel Derbyshire.jpg |
| Office: | Senator for Brockville, Ontario |
| Appointed: | Wilfrid Laurier |
| Term Start: | November 22, 1907 |
| Term End: | June 18, 1916 |
| Constituency Mp2: | Brockville |
| Parliament2: | Canadian |
| Predecessor2: | John Culbert |
| Successor2: | George Perry Graham |
| Term Start2: | 1904 |
| Term End2: | 1907 |
| Birth Date: | 11 December 1846 |
| Birth Place: | Plum Hollow, Leeds County, Canada West |
| Party: | Liberal |
Daniel Derbyshire (December 11, 1846 - June 18, 1916) was a Canadian politician.
Born in Plum Hollow, Leeds County, Canada West, the son of Harvey and Mary Derbyshire, Derbyshire was educated in Public Schools of the district and in the Athens High School. He received a first class normal certificate, after which he taught school for a few years. He later entered the dairy business and opened a Plum Hollow factory and another one in Athens. In 1881 he moved to Brockville, Ontario having accepted a position as representative of A. A. Ayer & Co. of Montreal. He later entered into the handling of butter and factory supplies. He was elected a member of the Brockville Council and was Mayor of Brockville in 1886 and 1889.
He was first elected to the House of Commons of Canada for the riding of Brockville in the general elections of 1904. In 1907, he was summoned to the Senate of Canada representing the senatorial division of Brockville, Ontario on the advice of Wilfrid Laurier. A Liberal, he served until his death in 1916.