Daledalin Explained

Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed.^{[1] [2] [3]} It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.^[4]

Synthesis

Daledalin can be prepared by the reduction of amedalin with diborane.

Notes and References

1. Book: Triggle, David J. . vanc . Dictionary of pharmacological agents . Chapman & Hall . London . 1997 . 978-0-412-46630-4 .
2. Cañas-Rodriguez A, Leeming PR . N-Phenyl-2-indolinones and N-phenylindolines. A new class of antidepressant agents . Journal of Medicinal Chemistry . 15 . 7 . 762–70 . July 1972 . 5043876. 10.1021/jm00277a017 .
3. Edwards JG, Ollerenshaw DP . Daledalin tosylate: a controlled trial in depressive illness . Current Medical Research and Opinion . 2 . 6 . 305–12 . 1974 . 4614944 . 10.1185/03007997409114763 .
4. Koe BK . Kenneth Koe . Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain . Journal of Pharmacology and Experimental Therapeutics . 199 . 3 . 649–661 . December 1976 . 994022.