| Daffiama-Bussie-Issa District | |
| Settlement Type: | District |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Daffiama-Bussie-Issa District within Upper West |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Name1: | Upper West |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Issa |
| Leader Title: | District Executive |
| Population As Of: | 2021 |
| Population Total: | 38,754[1] |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 10.3922°N -2.3325°W |
| Iso Code: | GH-UW-DB |
Daffiama-Bussie-Issa District is one of the eleven districts in Upper West Region, Ghana.[2] [3] [4] [5] Originally it was formerly part of the then-larger Nadowli District in 1988; until the eastern part of the district was later split off to create Daffiama-Bussie-Issa District on 28 June 2012; thus the remaining part has been renamed as Nadowli-Kaleo District. The district assembly is located in the western part of Upper West Region and has Issa as its capital town.