Dafachronic acid explained

Dafachronic acids are steroid hormones activate the nuclear receptor Daf-12/NR1J1 in Caenorhabditis elegans and related organisms, include Δ4-dafachronic acid and Δ7-dafachronic acid.[1] Both are generated by Daf-9/CYP22A1 from respective precursors.[2]

Notes and References

  1. Witting M, Rudloff HC, Thondamal M, Aguilaniu H, Schmitt-Kopplin P . Fast separation and quantification of steroid hormones Δ4- and Δ7-dafachronic acid in Caenorhabditis elegans . . 978-979 . 118–121 . 2015 . 25544008 . 10.1016/j.jchromb.2014.12.005 .
  2. Aguilaniu H, Fabrizio P, Witting M . The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry . . 7 . 12 . 2016 . 26903948 . 4749721 . 10.3389/fendo.2016.00012 . free .

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