Daf-9 Explained

Cytochrome P450 daf-9
Organism:Caenorhabditis elegans
Taxid:6239
Symbol:daf-9
Altsymbols:CYP22A1
Entrezgene:180889
Refseqmrna:NM_001029732.2
Refseqprotein:NP_001024903.1
Uniprot:H2KYS3
Chromosome:X
Entrezchromosome:NC_003284.9
Genloc Start:6196927
Genloc End:6200818

The Daf-9 gene encodes a cytochrome p450 enzyme catalysis the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans,[1] with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will binding it's nuclear receptor Daf-12 and has been implicated by Cynthia Kenyon and colleagues related to the formation of Dauer larva.[2]

References

  1. Jia K, Albert PS, Riddle DL. DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity . . 129 . 1 . 221–31 . 2002 . 10.1242/dev.129.1.221 . 11782415 .
  2. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R . A C. elegans mutant that lives twice as long as wild type . . 366 . 6454 . 1993 . 461–464 . 8247153 . 10.1038/366461a0. 1993Natur.366..461K . 4332206 .