Dactylosporangium aurantiacum explained

Dactylosporangium aurantiacum is a Gram-positive soil-based actinobacterium in the family Micromonosporaceae.^[1] Like all Dactylosporangium species, aurantiacum is aerobic and mesophilic.^[2]

One subspecies, hamdenesis, produces a number of 18-membered macrolide antibiotics called tiacumicins as a byproduct of fermentation.^[3] One of these, tiacumicin B, commonly known as fidaxomicin,^[4] has narrow-spectrum bacteriocidal action against Gram-positive anaerobic bacteria, including Clostridium difficile.

Notes and References

1. Web site: Dactylosporangium aurantiacum D-748 | Type strain | DSM 43157, ATCC 23491, IFO 12592, IMET 9028, JCM 3083, KCC A-0083, NBRC 12592, RIA 922, BCRC 13312, CBS 621.67, CECT 3288, CGMCC 4.1066, IFM 1208, IMSNU 22001, IMSNU 22064, KCTC 9073, MTCC 500, NCIMB 12887, NRRL B-8018, NRRL B-8111, VKM Ac-654 | BacDiveID:7869. Adam. Podstawka. bacdive.dsmz.de.
2. Book: Bergey's Manual of Systematic Bacteriology: Volume 5: The Actinobacteria.
3. 3610816 . 1987 . Hochlowski . J. E. . Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination . The Journal of Antibiotics . 40 . 5 . 575–88 . Swanson . S. J. . Ranfranz . L. M. . Whittern . D. N. . Buko . A. M. . McAlpine . J. B. . 10.7164/antibiotics.40.575. free .
4. 6005852. 2018. Baktash. A.. Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections. Frontiers in Microbiology. 9. 1242. Terveer. E. M.. Zwittink. R. D.. Hornung. B. V.. Corver. J.. Kuijper. E. J.. Smits. W. K.. 29946308. 10.3389/fmicb.2018.01242. free.