DYX1C1 explained

Dyslexia susceptibility 1 candidate gene 1 protein is a protein that in humans is encoded by the DYX1C1 gene.^{[1] [2]} This protein contains 420 amino acids with 3 tetratricopeptide repeat (TPR) domains, thought to mediate protein–protein interactions.

Clinical significance

A mutation in the DYX1C1 gene has been associated with deficits in reading ability (dyslexia).^{[1] [3]}

Further reading

• Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ . Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation . Mol. Psychiatry . 15. 12. 1190–6. November 2009 . 19901951 . 10.1038/mp.2009.120 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Brkanac Z, Chapman NH, Matsushita MM . Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 144 . 4 . 556–60 . 2007 . 17450541 . 10.1002/ajmg.b.30471 . 43864328 . etal.
• Cope NA, Hill G, van den Bree M . No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. . Mol. Psychiatry . 10 . 3 . 237–8 . 2005 . 15477871 . 10.1038/sj.mp.4001596 . 1777791 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Marino C, Citterio A, Giorda R . Association of short-term memory with a variant within DYX1C1 in developmental dyslexia. . . 6 . 7 . 640–6 . 2007 . 17309662 . 10.1111/j.1601-183X.2006.00291.x . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Scerri TS, Fisher SE, Francks C . Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK. . J. Med. Genet. . 41 . 11 . 853–7 . 2005 . 15520411 . 10.1136/jmg.2004.018341 . 1735619 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Wigg KG, Couto JM, Feng Y . Support for EKN1 as the susceptibility locus for dyslexia on 15q21. . Mol. Psychiatry . 9 . 12 . 1111–21 . 2005 . 15249932 . 10.1038/sj.mp.4001543 . etal. free .
• Ylisaukko-Oja T, Peyrard-Janvid M, Lindgren CM . Family-based association study of DYX1C1 variants in autism. . Eur. J. Hum. Genet. . 13 . 1 . 127–30 . 2005 . 15470369 . 10.1038/sj.ejhg.5201272 . etal. free .

Notes and References

1. Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T, Myllyluoma B, Lyytinen H, Muller K, Kaaranen M, Lindsberg PJ, Hannula-Jouppi K, Kere J . A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain . Proc Natl Acad Sci U S A . 100 . 20 . 11553–8 . Oct 2003 . 12954984 . 208796 . 10.1073/pnas.1833911100 . free .
2. Web site: Entrez Gene: DYX1C1 dyslexia susceptibility 1 candidate 1.
3. Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ . Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation . Mol. Psychiatry . 15. 12. 1190–6. November 2009 . 19901951 . 10.1038/mp.2009.120 . free .