DYNLT3 explained

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.^{[1] [2]}

Function

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase.^[3] DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.^[4]

Interactions

DYNLT3 has been shown to interact with VDAC1.^[5]

Further reading

• Roux AF, Rommens J, McDowell C . Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex . Hum. Mol. Genet. . 3 . 2 . 257–63 . 1994 . 8004092 . 10.1093/hmg/3.2.257 . etal.
• Bauch A, Campbell KS, Reth M . Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta . Eur. J. Immunol. . 28 . 7 . 2167–77 . 1998 . 9692886 . 10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L . 21656634 .
• Mueller S, Cao X, Welker R, Wimmer E . Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis . J. Biol. Chem. . 277 . 10 . 7897–904 . 2002 . 11751937 . 10.1074/jbc.M111937200 . free .
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N . Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74 . Int. J. Biochem. Cell Biol. . 34 . 9 . 1059–70 . 2002 . 12009301 . 10.1016/S1357-2725(02)00026-2 . 11632830 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Douglas MW, Diefenbach RJ, Homa FL . Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport . J. Biol. Chem. . 279 . 27 . 28522–30 . 2004 . 15117959 . 10.1074/jbc.M311671200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Yeh TY, Chuang JZ, Sung CH . Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway . J. Cell Sci. . 118 . Pt 15 . 3431–43 . 2005 . 16079286 . 10.1242/jcs.02472 . free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• O'Rourke SM, Dorfman MD, Carter JC, Bowerman B . Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants . PLOS Genet. . 3 . 8 . e128 . 2007 . 17676955 . 10.1371/journal.pgen.0030128 . 1937013 . free .

Notes and References

1. Web site: Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3.
2. Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M . Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex . Hum. Mol. Genet. . 3 . 2 . 257–63 . February 1994 . 8004092 . 10.1093/hmg/3.2.257 .
3. Lo KW, Kogoy JM, Pfister KK . The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3 . J. Biol. Chem. . 282 . 15 . 11205–12 . April 2007 . 17289665 . 10.1074/jbc.M611279200 . free .
4. Yeh TY, Chuang JZ, Sung CH . Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway . J. Cell Sci. . 118 . Pt 15 . 3431–43 . August 2005 . 16079286 . 10.1242/jcs.02472 . free .
5. 10.1016/S1357-2725(02)00026-2 . Schwarzer . Christian . Barnikol-Watanabe Shitsu . Thinnes Friedrich P . Hilschmann Norbert . Sep 2002 . Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74 . Int. J. Biochem. Cell Biol. . 34 . 9 . 1059–70 . 1357-2725. 12009301 . 11632830 .