DYNLT1 explained

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.^{[1] [2] [3]}

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]

Further reading

• Tete R, de Montgolfier R, Piante M . [Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography] . Journal de Médecine de Lyon . 52 . 192 . 1523–6 passim . 1971 . 5503857 .
• King SM, Dillman JF, Benashski SE . The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. . J. Biol. Chem. . 271 . 50 . 32281–7 . 1997 . 8943288 . 10.1074/jbc.271.50.32281 . etal. free .
• Nagano F, Orita S, Sasaki T . Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. . J. Biol. Chem. . 273 . 46 . 30065–8 . 1998 . 9804756 . 10.1074/jbc.273.46.30065 . etal. free .
• Strovel ET, Wu D, Sussman DJ . Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. . J. Biol. Chem. . 275 . 4 . 2399–403 . 2000 . 10644691 . 10.1074/jbc.275.4.2399 . free .
• Mueller S, Cao X, Welker R, Wimmer E . Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. . J. Biol. Chem. . 277 . 10 . 7897–904 . 2002 . 11751937 . 10.1074/jbc.M111937200 . free .
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N . Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74. . Int. J. Biochem. Cell Biol. . 34 . 9 . 1059–70 . 2002 . 12009301 . 10.1016/S1357-2725(02)00026-2 . 11632830 .
• Nadano D, Nakayama J, Matsuzawa S . Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton. . Biochem. J. . 364 . Pt 3 . 669–77 . 2002 . 12049630 . 10.1042/BJ20011836 . 1222615 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Machado RD, Rudarakanchana N, Atkinson C . Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. . Hum. Mol. Genet. . 12 . 24 . 3277–86 . 2004 . 14583445 . 10.1093/hmg/ddg365 . etal. free .
• Douglas MW, Diefenbach RJ, Homa FL . Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. . J. Biol. Chem. . 279 . 27 . 28522–30 . 2004 . 15117959 . 10.1074/jbc.M311671200 . etal. free .
• Ohka S, Matsuda N, Tohyama K . Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. . J. Virol. . 78 . 13 . 7186–98 . 2004 . 15194795 . 10.1128/JVI.78.13.7186-7198.2004 . 421661 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• de Wit NJ, Verschuure P, Kappé G . Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1. . Eur. J. Cell Biol. . 83 . 7 . 337–45 . 2005 . 15503857 . 10.1078/0171-9335-00396 . etal.
• Chuang JZ, Yeh TY, Bollati F . The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. . Dev. Cell . 9 . 1 . 75–86 . 2005 . 15992542 . 3857739 . 10.1016/j.devcel.2005.04.003 . etal.
• Yeh TY, Peretti D, Chuang JZ . Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. . Traffic . 7 . 11 . 1495–502 . 2007 . 16956385 . 10.1111/j.1600-0854.2006.00482.x . etal. 3873093 .

Notes and References

1. Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y . Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q . Cytogenet Cell Genet . 73 . 1–2 . 153–6 . Jul 1996 . 8646886 . 10.1159/000134329 .
2. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB . Cytoplasmic dynein nomenclature . J Cell Biol . 171 . 3 . 411–3 . Nov 2005 . 16260502 . 2171247 . 10.1083/jcb.200508078 .
3. Web site: Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1.